Cytotoxic cucurbitane triterpenoids isolated from the rhizomes of Hemsleya amabilis

doi:10.1016/j.fitote.2014.01.014

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	Cytotoxic cucurbitane triterpenoids isolated from the rhizomes of Hemsleya amabilis
	Chen, Xu-Bing 1,2; Chen, Guang-Yong 1; Liu, Jun-Hua 2; Lei, Min2 ; Meng, Yu-Hui 2; Guo, De-An2 ; Liu, Xuan 2; Hu, Li-Hong 2
刊名	FITOTERAPIA
	2014-04
卷号	94 页码:88-93
关键词	Hemsleya amabilis Cucurbitaceae Triterpenoid Cytotoxicity HeLa cell
ISSN号	0367-326X
DOI	10.1016/j.fitote.2014.01.014
文献子类	Article
英文摘要	Two new cucurbitane triterpenoids, 7 beta-hydroxycucurbitacin F-25-O-acetate (1) and 2 beta,3 beta,20 (S),26,27-pentahydroxy-16 alpha,23(S)-epoxycucurbita-5,24-dien-11-one (2) along with eleven known cucurbitane triterpenoids (3-13, resp.) were isolated from the rhizomes of Hemsleya amabilis Diels. The chemical structures of the new isolated compounds were elucidated unambiguously by spectroscopic data analysis. The cytotoxic activities of the isolated cucurbitane triterpenoids were evaluated against the HeLa human cancer cell lines. Hemslecin A (5), the main ingredient of H. amabilis, exhibited the significant cytotoxicity with IC50 value of 0389 mu M. (C) 2014 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000335608700011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277127]
专题	上海中药现代化研究中心
通讯作者	Liu, Xuan
作者单位	1.Dali Univ, Coll Pharm, Dali 671000, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Chen, Xu-Bing,Chen, Guang-Yong,Liu, Jun-Hua,et al. Cytotoxic cucurbitane triterpenoids isolated from the rhizomes of Hemsleya amabilis[J]. FITOTERAPIA,2014,94:88-93.
APA	Chen, Xu-Bing.,Chen, Guang-Yong.,Liu, Jun-Hua.,Lei, Min.,Meng, Yu-Hui.,...&Hu, Li-Hong.(2014).Cytotoxic cucurbitane triterpenoids isolated from the rhizomes of Hemsleya amabilis.FITOTERAPIA,94,88-93.
MLA	Chen, Xu-Bing,et al."Cytotoxic cucurbitane triterpenoids isolated from the rhizomes of Hemsleya amabilis".FITOTERAPIA 94(2014):88-93.