Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis

doi:10.1016/j.ejmech.2014.07.043

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	Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis
	Yang, Zhiyou 3; Liu, Zhihui 3; Jiang, Baohong2 ; Teng, Fukang 2,3; Wang, Yu 1; Han, Na 3; Guo, Dean2 ; Yin, Jun 3
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2014-09-12
卷号	84 页码:417-424
关键词	Dihydrobenzophenanthridine alkaloids Corydalis ambigua var. amurensis X-ray diffraction Enantiomers Antimyocardial hypoxia
ISSN号	0223-5234
DOI	10.1016/j.ejmech.2014.07.043
文献子类	Article
英文摘要	Ten new scarce dihydrobenzophenanthridine alkaloids, including seven monomers, ambidalmines A(1/2), B-1/2-E (1(a/b), 2(a/b),-5) and three dimers, ambidimerines F-1 (6a), F-2 (6b) and F-3 (6c), were isolated from the tubers of Corydalis ambigua var. amurensis. All of these compounds were discovered in the forms of enantiomers. The structures were elucidated based on extensive spectroscopic analysis, with absolute configurations of the enantiomeric compounds assigned by single-crystal X-ray diffraction analysis, circular dichroism (CD) and optical rotations. Bioactivity evaluation showed that compounds 1a, 2a, 2b and 6b exhibit comparable protective effects on hypoxic H9C2 cells. (C) 2014 Elsevier Masson SAS. All rights reserved.
WOS关键词	MYOCARDIAL-ISCHEMIA INJURY ; BENZOPHENANTHRIDINE ALKALOIDS ; CONSTITUENTS ; CARDIOPROTECTION
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号	WOS:000341464500038
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276904]
专题	上海中药现代化研究中心
通讯作者	Yin, Jun
作者单位	1.Chinese Peoples Liberat Army 463 Hosp, Shenyang 110042, Peoples R China 2.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Dev & Utilizat Key Lab Northeast Plant Mat, Shenyang 110016, Peoples R China;
推荐引用方式 GB/T 7714	Yang, Zhiyou,Liu, Zhihui,Jiang, Baohong,et al. Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2014,84:417-424.
APA	Yang, Zhiyou.,Liu, Zhihui.,Jiang, Baohong.,Teng, Fukang.,Wang, Yu.,...&Yin, Jun.(2014).Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,84,417-424.
MLA	Yang, Zhiyou,et al."Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 84(2014):417-424.