Pharmacokinetic Studies of Ganoderic Acids from the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), by LC-MS/MS

doi:10.1615/IntJMedMushrooms.v18.i5.40

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	Pharmacokinetic Studies of Ganoderic Acids from the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), by LC-MS/MS
	Cheng, Chun-Ru 1,2; Ding, Jie 2; Yang, Yi 2; Liang, Xin-Yong 2; Guo, De-An1 ; Yang, Min 1; Guan, Shu-Hong1
刊名	INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
	2016
卷号	18 期号:5 页码:405-412
关键词	ganoderic acid Ganoderma lucidum LC-MS/MS medicinal mushrooms quantification pharmacokinetics
ISSN号	1521-9437
DOI	10.1615/IntJMedMushrooms.v18.i5.40
文献子类	Article
英文摘要	Ganoderma lucidum is a famous medicinal mushroom that has been widely used in clinical practice and as a dietary supplementa. The triterpenoid ganoderic acids are the main constituents of G. lucidum. To determine the pharmacokinetic characteristics of ganoderic acids, we developed and validated a sensitive and selective liquid chromatography-tandem mass spectrometry method to determine simultaneously the concentration of 4 representative ganoderic acids in rat plasma after oral administration of the extract from G. lucidum. Because of the similarity of their chemical structures, the 4 components exhibited similar pharmacokinetic behaviors in some aspects. However, some of the pharmacokinetic parameters and the reabsorption peaks in the plasma concentration-time curves of ganoderic acids B and E after oral administration of the extract were different from those of ganoderic acids D and A because of the metabolic transformation among the ganoderic acids. These results increase our knowledge about the use of G. lucidum.
资助项目	Discipline Construction Project of Sichuan University of Science & Engineering, Introduction Program of Scientific Researchist of Sichuan University of Science Engineering[2012RC17] ; Discipline Construction Project of Sichuan University of Science & Engineering, Introduction Program of Scientific Researchist of Sichuan University of Science Engineering[2012RC15] ; Opening Project of Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education[LYJ1302] ; Scientific Research Fund of the Sichuan Provincial Education Department[13ZB0133] ; Science and Technology Programme Project of Sichuan[2015JY0024]
WOS关键词	TANDEM MASS-SPECTROMETRY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; TRITERPENOIDS ; IDENTIFICATION ; EXTRACT
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences ; Mycology ; Pharmacology & Pharmacy
语种	英语
出版者	BEGELL HOUSE INC
WOS记录号	WOS:000383945900004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276201]
专题	上海中药现代化研究中心
通讯作者	Cheng, Chun-Ru
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Natl Engn Lab TCM Standardizat Technol,Shanghai R, Shanghai, Peoples R China 2.Sichuan Univ Sci & Engn, Sichuan Inst Higher Educ, Key Lab Green Chem, Inst Pharmaceut Engn Technol & Applicat,Sch Chem, Xueyuan St 180,Huixing Rd, Zigong 643000, Sichuan, Peoples R China;
推荐引用方式 GB/T 7714	Cheng, Chun-Ru,Ding, Jie,Yang, Yi,et al. Pharmacokinetic Studies of Ganoderic Acids from the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), by LC-MS/MS[J]. INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,2016,18(5):405-412.
APA	Cheng, Chun-Ru.,Ding, Jie.,Yang, Yi.,Liang, Xin-Yong.,Guo, De-An.,...&Guan, Shu-Hong.(2016).Pharmacokinetic Studies of Ganoderic Acids from the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), by LC-MS/MS.INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,18(5),405-412.
MLA	Cheng, Chun-Ru,et al."Pharmacokinetic Studies of Ganoderic Acids from the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), by LC-MS/MS".INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS 18.5(2016):405-412.