Plasma Amino Acid Profile in Patients with Aortic Dissection

doi:10.1038/srep40146

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 上海中药现代化研究中心

	Plasma Amino Acid Profile in Patients with Aortic Dissection
	Wang, Linlin 1; Liu, Sha 3,4; Yang, Wengang 4; Yu, Haitao 1; Zhang, Li 1; Ma, Ping 2; Wu, Peng 1; Li, Xue 1; Cho, Kenka 5; Xue, Song 4
刊名	SCIENTIFIC REPORTS
	2017-01-10
卷号	7
ISSN号	2045-2322
DOI	10.1038/srep40146
文献子类	Article
英文摘要	Aortic dissection (AD), a severe cardiovascular disease with the characteristics of high mortality, is lack of specific clinical biomarkers. In order to facilitate the diagnosis of AD, we investigated plasma amino acid profile through metabolomics approach. Total 33 human subjects were enrolled in the study: 11 coronary heart disease (CHD) patients without aortic lesion and 11 acute AD and 11 chronic AD. Amino acids were identified in plasma using liquid chromatography and mass spectrometry (LC-MS/MS), and were further subjected to multiple logistic regression analysis. The score plots of principal component analysis (PCA) and partial least squares-discriminate analysis (PLS-DA) showed clear discrimination of CHD patients with AD, acute AD or chronic AD patients, respectively. The contents of histidine, glycine, serine, citrate, ornithine, hydroxyproline, proline and sarcosine were significant different in acute AD patients comparing with CHD patients. The levels of citrate, GABA, glutamate and cysteine were significant different in chronic AD patients comparing with CHD patients. The contents of glutamate and phenylalanine were significant changed in acute AD patients comparing with chronic AD patients. Plasma aminograms were significantly altered in patients with AD comparing with CHD, especially in acute AD, suggesting amino acid profile is expected to exploit a novel, non-invasive, objective diagnosis for AD.
资助项目	Shanghai Science and Technology Development Foundation[14401900900] ; International Cooperation Bureau of the Chinese Academy of Sciences for Key Projects of Foreign Cooperation[GJHZ1616] ; Croucher Foundation[CAS14201] ; National Natural Science Foundation of China[81573646]
WOS关键词	ADIPOSE-TISSUE DEVELOPMENT ; ARGININE NUTRITION ; MASS-SPECTROMETRY ; BREAST-CANCER ; GLYCINE ; CHROMATOGRAPHY ; MECHANISM ; DISEASE ; SHEEP
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000392231600001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275680]
专题	上海中药现代化研究中心
通讯作者	Xue, Song; Jiang, Baohong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Second Artillery Gen Hosp PLA, Beijing 100088, Peoples R China; 3.Covidien Shanghai Management Consulting Co Ltd, Shanghai 200233, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Cardiovasc Surg, Shanghai 200127, Peoples R China; 5.Takarazuka Univ Med & Hlth Care, Takarazuka, Hyogo 6660162, Japan
推荐引用方式 GB/T 7714	Wang, Linlin,Liu, Sha,Yang, Wengang,et al. Plasma Amino Acid Profile in Patients with Aortic Dissection[J]. SCIENTIFIC REPORTS,2017,7.
APA	Wang, Linlin.,Liu, Sha.,Yang, Wengang.,Yu, Haitao.,Zhang, Li.,...&Jiang, Baohong.(2017).Plasma Amino Acid Profile in Patients with Aortic Dissection.SCIENTIFIC REPORTS,7.
MLA	Wang, Linlin,et al."Plasma Amino Acid Profile in Patients with Aortic Dissection".SCIENTIFIC REPORTS 7(2017).