Arcuate nucleus of hypothalamus involved in analgesic action of l-THP

	Arcuate nucleus of hypothalamus involved in analgesic action of l-THP
	Hu, JY; Jin, GZ
刊名	ACTA PHARMACOLOGICA SINICA
	2000-05
卷号	21 期号:5 页码:439-444
关键词	tetrahydropalmatine horseradish peroxidase arcuate nucleus PAG corpus striatum nucleus accumbens analgesia naloxone endorphins
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To study the role of the arcuate nucleus of hypothalamus in analgesic action of l-tetrahydropalmatine ( I-THP). METHODS: The horseradish peroxidase (HRP) retrograde tracing, HRP retrograde tracing combined with immunohistochemistry, lesion of nucleus, tail- flick test, and intra-PAG injection were used in the present study. RESULTS: HRP retrograde tracing results showed that the striatum or accumbens nucleus connect with PAG by two pathways: 1) striatum or accumbens nucleus --> arcuate nucleus --> PAG; 2) striatum or accumbens nucleus --> habenula --> PAG. It was found that neurons in the arcuate nucleus projecting to PAG were mainly beta-endorphin neurons as observed by HRP retrograde tracing combined with immuno-histochemistry. After lesion of the arcuate nucleus, the analgesic action of l-THP (40 mg.kg(-1), ip) was abolished, while lesion of the habenula had no such effect. Moreover, intra-PAG injection of naloxone (2, 3 mu g) could markedly attenuate the analgesic action of E-THP (40 mg kg-l, ip) in a dose-dependent manner. CONCLUSION: beta-Endorphin neurons in the arcuate nucleus play an important role in the analgesic action of l-THP.
WOS关键词	PERIAQUEDUCTAL GRAY ; DESCENDING PATHWAY ; ACCUMBENS ; TETRAHYDROPROTOBERBERINES ; HABENULA
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000086866500011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274622]
专题	院士及顾问专家
通讯作者	Jin, GZ
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Hu, JY,Jin, GZ. Arcuate nucleus of hypothalamus involved in analgesic action of l-THP[J]. ACTA PHARMACOLOGICA SINICA,2000,21(5):439-444.
APA	Hu, JY,&Jin, GZ.(2000).Arcuate nucleus of hypothalamus involved in analgesic action of l-THP.ACTA PHARMACOLOGICA SINICA,21(5),439-444.
MLA	Hu, JY,et al."Arcuate nucleus of hypothalamus involved in analgesic action of l-THP".ACTA PHARMACOLOGICA SINICA 21.5(2000):439-444.