Withaphysanolide A, a novel C-27 norwithanolide skeleton, and other cytotoxic compounds from Physalis divericata

doi:10.1016/j.tetlet.2006.11.081

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 上海中药现代化研究中心

	Withaphysanolide A, a novel C-27 norwithanolide skeleton, and other cytotoxic compounds from Physalis divericata
	Ma, Lei ; Ali, Mumtaz ; Arfan, Mohammad ; Lou, Li-Guang; Hu, Li-Hong
刊名	TETRAHEDRON LETTERS
	2007-01-15
卷号	48 期号:3 页码:449-452
关键词	norwithanolides Physalis divericata withaphysanolide A cytotoxicity
ISSN号	0040-4039
DOI	10.1016/j.tetlet.2006.11.081
文献子类	Article
英文摘要	A novel C-27 norwithasteroid, withaphysanolide A (1) containing a pyran ring was isolated from the aerial parts of Physalis divericata. Four known withaphysalins (2-5) and five physalins (6-10) were also isolated. The structural assignment for I was done based on spectroscopic and single-crystal X-ray diffraction data. Logical biosynthetic pathways were postulated. Compounds 6, 7, and 10 displayed potent cytotoxic activity against HCT-116 and H460 human cancer cell lines, with IC50 values less than 2.0 mu M. (c) 2006 Elsevier Ltd. All rights reserved.
WOS关键词	VAR INDICA ; ANGULATA ; WITHANOLIDES ; LANCIFOLIA
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000243819100026
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273356]
专题	上海中药现代化研究中心
通讯作者	Lou, Li-Guang
作者单位	1.Univ Peshawar, Inst Chem Sci, Peshawar, Pakistan 2.Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Ma, Lei,Ali, Mumtaz,Arfan, Mohammad,et al. Withaphysanolide A, a novel C-27 norwithanolide skeleton, and other cytotoxic compounds from Physalis divericata[J]. TETRAHEDRON LETTERS,2007,48(3):449-452.
APA	Ma, Lei,Ali, Mumtaz,Arfan, Mohammad,Lou, Li-Guang,&Hu, Li-Hong.(2007).Withaphysanolide A, a novel C-27 norwithanolide skeleton, and other cytotoxic compounds from Physalis divericata.TETRAHEDRON LETTERS,48(3),449-452.
MLA	Ma, Lei,et al."Withaphysanolide A, a novel C-27 norwithanolide skeleton, and other cytotoxic compounds from Physalis divericata".TETRAHEDRON LETTERS 48.3(2007):449-452.