Malonylginsenosides with Potential Antidiabetic Activities from the Flower Buds of Panax ginseng

doi:10.1021/acs.jnatprod.6b00789

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	Malonylginsenosides with Potential Antidiabetic Activities from the Flower Buds of Panax ginseng
	Qiu, Shi 1; Yang, Wen-Zhi 1; Yao, Chang-Liang 1; Shi, Xiao-Jian 1; Li, Jing-Ya2 ; Lou, Yang 2; Duan, Ya-Nan 2; Wu, Wan-Ying1 ; Guo, De-An1
刊名	JOURNAL OF NATURAL PRODUCTS
	2017-04
卷号	80 期号:4 页码:899-908
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.6b00789
文献子类	Article
英文摘要	LC-MS-guided pliytocheinical isolation of malonylginsenosides, featuring neutral elimination of CO2 and C3H2O3 by the negative mode collision-induced dissociation, from the flower buds of Panax ginseng led to the isolation of 19 malonylsubstituted triterpenoid saponins. They include 15 new malonylginsenosides, malonylfloralginsenosides-Re-1-Re-3 (1-3), -Rb-1 and -Rb-2 (4, 5), -Rd(1)-Rd(6) (6=11), and -Rc(1)-Rc(4) (12-15); and the known m-Rb-1, m-Rc, m-Rb-2, and m-Rd (16-19). CompOund 11 represents the first dimalunyl saponin isolated from the Panax genus, while 2-4, 9, :and TO are five,ginsenosides with single malonylation at the C-20 sugar. chain. The antidiabetic activities of nine of these malonyl-substituted ginsenosides (1, 3, 4, 8, 13, and 16-19) arid five of the corresponding non-malonyl ginsenosides (Re, Rb-1, Rb-2, Rc, and Rd) were evaluated by L6 myotubes' glucose consumption and AMPK alpha 2 beta 1 gamma 1 activation. Ginsenoside Rb-2, 1, and 18 promoted glucose consumption of differentiated L6 imyotubes, while ginsenosides Rb-1, Rb-2, and Rd and the malonylginsenosides 4, 8, 13, 16, 17, arid 19 activated AMPK alpha 2 beta 1 gamma 1 (EC50: 0:0168-2.8 mu M, fold: 1.7-4.7).
资助项目	National Natural Science Foundation of China[81503240] ; National Natural Science Foundation of China[81473344] ; National Natural Science Foundation of China[81470166]
WOS关键词	CHROMATOGRAPHY/MASS SPECTROMETRY ANALYSIS ; MALONYL-GINSENOSIDES ; COLUMN CHROMATOGRAPHY ; EFFICIENT DISCOVERY ; CHEMICAL DIVERSITY ; DIABETES-MELLITUS ; NATURAL COMPOUNDS ; FRESH ROOT ; SAPONINS ; NOTOGINSENG
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000400538800015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272714]
专题	上海中药现代化研究中心
通讯作者	Wu, Wan-Ying; Guo, De-An
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, Haike Rd 501, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Zuchongzhi Rd 555, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Qiu, Shi,Yang, Wen-Zhi,Yao, Chang-Liang,et al. Malonylginsenosides with Potential Antidiabetic Activities from the Flower Buds of Panax ginseng[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(4):899-908.
APA	Qiu, Shi.,Yang, Wen-Zhi.,Yao, Chang-Liang.,Shi, Xiao-Jian.,Li, Jing-Ya.,...&Guo, De-An.(2017).Malonylginsenosides with Potential Antidiabetic Activities from the Flower Buds of Panax ginseng.JOURNAL OF NATURAL PRODUCTS,80(4),899-908.
MLA	Qiu, Shi,et al."Malonylginsenosides with Potential Antidiabetic Activities from the Flower Buds of Panax ginseng".JOURNAL OF NATURAL PRODUCTS 80.4(2017):899-908.