Fabrication of nanomicelle with enhanced solubility and stability of camptothecin based on alpha,beta-poly[(N-carboxybutyl)-L-aspartamide]-camptothecin conjugate

doi:10.1016/j.colsurfb.2009.09.034

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Fabrication of nanomicelle with enhanced solubility and stability of camptothecin based on alpha,beta-poly[(N-carboxybutyl)-L-aspartamide]-camptothecin conjugate
	Fan, Naiqian 4; Duan, Kongrong 4; Wang, Chengyun 4; Liu, Shunying 4; Luo, Shufang 4; Yu, Jiahui 4; Huang, Jin 3,4; Li, Yaping1 ; Wang, Daxin 2
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2010-02-01
卷号	75 期号:2 页码:543-549
关键词	alpha,beta-Poly[(N-carboxybutyl)-L-aspartamide] Camptothecin Nanomicelles Cytotoxicity Stability Solubility
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2009.09.034
文献子类	Article
英文摘要	This research is aimed to develop a nanomicelle delivery system in order to enhance the solubility and stability of camptothecin (CPT) in aqueous media. In this case, alpha,beta-poly[(N-carboxybutyl)-L-aspartamide] (PBAsp)-CPT was conjugated by the esterification between PBAsp and 20-OH of CPT, and hence used to fabricate nanomicelles with a particle size between the pore size of blood capillary in normal tissue and that in tumor tissue. It was worthy of note that the drug-loaded system of PBAsp-CPT nanomicelle improved the solubility and stability of CPT in aqueous media. However, with an increase of the CPT loading in PBAsp-CPT, the solubility sharply decreased. Meanwhile, the sizes of PBAsp-CPT nanomicelles showed a tendency of increase. Moreover, the drug release of PBAsp-CPT nanomicelles displayed a linear sustaining profile, and hence resulted in the essential decrease of cytotoxicity to L929 cell line. The assembled nanomicelles based on the PBAsp-CPT conjugates showed a great potential as polymer prodrug of tumor therapy, and the controlled nano-scale might achieve the passive tumor targeting. (C) 2009 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[20504010] ; Chinese Ministry of Science and Technology[2007CB936104] ; Chinese Ministry of Science and Technology[2009CB930000] ; Chinese Ministry of Science and Technology[2009CB930300] ; Shanghai Municipality Commission for Special Project of Nanometer Science and Technology[0852nm03700] ; Shanghai Municipality Commission for Special Project of Nanometer Science and Technology[0952nm05300] ; Shanghai Municipality Commission for Non-governmental International Corporation Project[09540709000]
WOS关键词	IN-VITRO CYTOTOXICITY ; ANTITUMOR-ACTIVITY ; ALBUMINS ; ANALOGS ; SERUM
WOS研究方向	Biophysics ; Chemistry ; Materials Science
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000276921900023
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278980]
专题	药物制剂研究中心
通讯作者	Yu, Jiahui
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; 2.Yangzhou Univ, Subei Hosp Jiangsu Prov, Yangzhou 225001, Peoples R China 3.Wuhan Univ Technol, Coll Chem Engn, Wuhan 430070, Peoples R China; 4.E China Normal Univ, Inst Adv Interdisciplinary Res, Shanghai 200062, Peoples R China;
推荐引用方式 GB/T 7714	Fan, Naiqian,Duan, Kongrong,Wang, Chengyun,et al. Fabrication of nanomicelle with enhanced solubility and stability of camptothecin based on alpha,beta-poly[(N-carboxybutyl)-L-aspartamide]-camptothecin conjugate[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2010,75(2):543-549.
APA	Fan, Naiqian.,Duan, Kongrong.,Wang, Chengyun.,Liu, Shunying.,Luo, Shufang.,...&Wang, Daxin.(2010).Fabrication of nanomicelle with enhanced solubility and stability of camptothecin based on alpha,beta-poly[(N-carboxybutyl)-L-aspartamide]-camptothecin conjugate.COLLOIDS AND SURFACES B-BIOINTERFACES,75(2),543-549.
MLA	Fan, Naiqian,et al."Fabrication of nanomicelle with enhanced solubility and stability of camptothecin based on alpha,beta-poly[(N-carboxybutyl)-L-aspartamide]-camptothecin conjugate".COLLOIDS AND SURFACES B-BIOINTERFACES 75.2(2010):543-549.