Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique

doi:10.3109/02652048.2011.599442

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique
	Gao, Yiping; Zhu, Chun-Liu; Zhang, Xin-Xin; Gan, Li; Gan, Yong
刊名	JOURNAL OF MICROENCAPSULATION
	2011
卷号	28 期号:6 页码:549-556
关键词	colon-specific drug delivery Compritol 888 ATO Eudragit S100 microspheres ultrasonic spray freeze-drying
ISSN号	0265-2048
DOI	10.3109/02652048.2011.599442
文献子类	Article
英文摘要	Lipid-polymer composite microspheres (LP-MS) for colon-specific drug delivery were prepared using an ultrasonic spray freeze-drying technique. These microspheres, which consist of the pH-sensitive polymer Eudragit S100 and the non-polar lipid Compritol 888 ATO, were characterized by morphological and physicochemical properties. It was found that the LP-MS have a spherical lipid porous matrix with a smooth pH-sensitive polymer film on both internal and external surfaces, and the insoluble drug 10-hydroxycamptothecin was dispersed in an amorphous state in the carrier. Morphological changes of microparticles under different pH conditions were observed by confocal laser scanning microscopy, which showed that the lipid matrix in LP-MS restricted the swelling property of the polymer at pH 6.8. In drug release studies, less than 15% of the drug was released below pH 6.8, whereas more than 30% was released with a sustained-release model at pH 7.4. The LP-MS could provide a promising vehicle for colon drug delivery.
资助项目	National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program''[2009ZX09301-001] ; National Basic Research Program of China[2009CB930300]
WOS关键词	WATER-SOLUBLE DRUGS ; RELEASE ; MICROPARTICLES ; DESIGN ; SYSTEM ; TACROLIMUS ; TIME ; PEG
WOS研究方向	Chemistry ; Engineering ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000293744700010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278661]
专题	药物制剂研究中心
通讯作者	Gan, Yong
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Gao, Yiping,Zhu, Chun-Liu,Zhang, Xin-Xin,et al. Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique[J]. JOURNAL OF MICROENCAPSULATION,2011,28(6):549-556.
APA	Gao, Yiping,Zhu, Chun-Liu,Zhang, Xin-Xin,Gan, Li,&Gan, Yong.(2011).Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique.JOURNAL OF MICROENCAPSULATION,28(6),549-556.
MLA	Gao, Yiping,et al."Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique".JOURNAL OF MICROENCAPSULATION 28.6(2011):549-556.