Visualization of mouse spinal cord intramedullary arteries using phase- and attenuation-contrast tomographic imaging

doi:10.1107/S1600577516006482

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 分子影像中心（筹）

	Visualization of mouse spinal cord intramedullary arteries using phase- and attenuation-contrast tomographic imaging
	Cao, Yong 3; Yin, Xianzhen 1; Zhang, Jiwen1 ; Wu, Tianding 3; Li, Dongzhe 3; Lu, Hongbin 2; Hu, Jianzhong 3
刊名	JOURNAL OF SYNCHROTRON RADIATION
	2016-07
卷号	23 页码:966-974
关键词	intramedullary arteries phase-contrast imaging attenuation-contrast imaging high resolution
ISSN号	1600-5775
DOI	10.1107/S1600577516006482
文献子类	Article
英文摘要	Many spinal cord circulatory disorders present the substantial involvement of small vessel lesions. The central sulcus arteries supply nutrition to a large part of the spinal cord, and, if not detected early, lesions in the spinal cord will cause irreversible damage to the function of this organ. Thus, early detection of these small vessel lesions could potentially facilitate the effective diagnosis and treatment of these diseases. However, the detection of such small vessels is beyond the capability of current imaging techniques. In this study, an imaging method is proposed and the potential of phase-contrast imaging (PCI)- and attenuation-contrast imaging (ACI)-based synchrotron radiation for high-resolution tomography of intramedullary arteries in mouse spinal cord is validated. The three-dimensional vessel morphology, particularly that of the central sulcus arteries (CSA), detected with these two imaging models was quantitatively analyzed and compared. It was determined that both PCI- and ACI-based synchrotron radiation can be used to visualize the physiological arrangement of the entire intramedullary artery network in the mouse spinal cord in both two dimensions and three dimensions at a high-resolution scale. Additionally, the two-dimensional and three-dimensional vessel morphometric parameter measurements obtained with PCI are similar to the ACI data. Furthermore, PCI allows efficient and direct discrimination of the same branch level of the CSA without contrast agent injection and is expected to provide reliable biological information regarding the intramedullary artery. Compared with ACI, PCI might be a novel imaging method that offers a powerful imaging platform for evaluating pathological changes in small vessels and may also allow better clarification of their role in neurovascular disorders.
资助项目	National Natural Science Foundation of China[81171698] ; National Natural Science Foundation of China[81301542] ; National Natural Science Foundation of China[81371956] ; Hunan Provincial Innovation Foundation For Postgraduate[CX2015B060]
WOS关键词	SCANNING-ELECTRON-MICROSCOPY ; VASCULAR CORROSION CASTS ; X-RAY TOMOGRAPHY ; SYNCHROTRON-RADIATION ; HIGH-RESOLUTION ; MEDICAL APPLICATIONS ; COMPUTED-TOMOGRAPHY ; 3-DIMENSIONAL ANALYSIS ; INJURY ; ANGIOGRAPHY
WOS研究方向	Instruments & Instrumentation ; Optics ; Physics
语种	英语
出版者	INT UNION CRYSTALLOGRAPHY
WOS记录号	WOS:000379954600015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275972]
专题	分子影像中心（筹）药物制剂研究中心
通讯作者	Lu, Hongbin; Hu, Jianzhong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 20203, Peoples R China; 2.Cent S Univ, Xiangya Hosp, Res Ctr Sports Med, Dept Sports Med, Changsha 410008, Hunan, Peoples R China 3.Cent S Univ, Xiangya Hosp, Dept Spine Surg, Changsha 410008, Hunan, Peoples R China;
推荐引用方式 GB/T 7714	Cao, Yong,Yin, Xianzhen,Zhang, Jiwen,et al. Visualization of mouse spinal cord intramedullary arteries using phase- and attenuation-contrast tomographic imaging[J]. JOURNAL OF SYNCHROTRON RADIATION,2016,23:966-974.
APA	Cao, Yong.,Yin, Xianzhen.,Zhang, Jiwen.,Wu, Tianding.,Li, Dongzhe.,...&Hu, Jianzhong.(2016).Visualization of mouse spinal cord intramedullary arteries using phase- and attenuation-contrast tomographic imaging.JOURNAL OF SYNCHROTRON RADIATION,23,966-974.
MLA	Cao, Yong,et al."Visualization of mouse spinal cord intramedullary arteries using phase- and attenuation-contrast tomographic imaging".JOURNAL OF SYNCHROTRON RADIATION 23(2016):966-974.