Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer

doi:10.1002/adhm.201600283

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer
	Wang, Fengyang 3; Sun, Qianqian 3; Feng, Bing 1; Xu, Zhiai 3; Zhang, Junying 3; Xu, Jie 3; Lu, Linlin 3; Yu, Haijun1 ; Wang, Mingwei2 ; Li, Yaping1
刊名	ADVANCED HEALTHCARE MATERIALS
	2016-09-07
卷号	5 期号:17 页码:2227-2236
关键词	chemotherapy dopamine gold nanostar graphene oxide photothermal therapy
ISSN号	2192-2640
DOI	10.1002/adhm.201600283
文献子类	Article
英文摘要	Breast cancer is the leading cancer type diagnosed in the female population, and cancer metastasis is the main reason for cancer-caused mortality. A novel nanoplatform is herein presented integrating polydopamine-functionalized nanosized reduced graphene oxide (NRGO), gold nanostars (GNS), and doxorubicin (DOX) (denoted as NRGO-GNS@DOX) for combinational treatment of metastatic breast cancer. Upon localized near infrared (NIR) laser irradiation, the NRGO-GNS@DOX nanocomposites induce significant cytotoxicity in 4T1 breast cancer cells due to a cumulative therapy effect of NRGO-GNS-elicited hyperthermia and DOX-induced cytotoxicity. Antitumor studies in orthotopic 4T1 breast tumor-bearing nude mice demonstrate that NRGO-GNS@DOX in combination with NIR laser irradiation inhibit the tumor growth and suppress the lung metastasis. Contribution of DOX-caused apoptosis of the cancer cells and hyperthermia-induced deconstruction of the tumor-associated blood vessels may account for the superior antitumor performance of the NRGO-GNS@DOX nanocomposites. These results imply a good potential of NRGO-GNS@DOX for combined photothermal and chemotherapy of the metastatic cancer.
资助项目	National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[21305047] ; National Natural Science Foundation of China[21375040]
WOS关键词	IN-VIVO ; DRUG-DELIVERY ; STEM-CELLS ; THERAPY ; NANORODS ; TUMOR ; NANOPARTICLES ; GENOTOXICITY ; NANOSHEETS ; CHEMISTRY
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000383776300009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275896]
专题	药物制剂研究中心
通讯作者	Xu, Zhiai; Zhang, Wen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 2.Fudan Univ, Dept Nucl Med, Shanghai Canc Ctr, Shanghai 200032, Peoples R China 3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Fengyang,Sun, Qianqian,Feng, Bing,et al. Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer[J]. ADVANCED HEALTHCARE MATERIALS,2016,5(17):2227-2236.
APA	Wang, Fengyang.,Sun, Qianqian.,Feng, Bing.,Xu, Zhiai.,Zhang, Junying.,...&Zhang, Wen.(2016).Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer.ADVANCED HEALTHCARE MATERIALS,5(17),2227-2236.
MLA	Wang, Fengyang,et al."Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer".ADVANCED HEALTHCARE MATERIALS 5.17(2016):2227-2236.