Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload

doi:10.1039/c7ra02306e

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload
	Singh, Vikramjeet 2,3; Guo, Tao 2; Wu, Li 2; Xu, Jianghui 2; Liu, Botao 2; Gref, Ruxandra 1; Zhang, Jiwen2
刊名	RSC ADVANCES
	2017
卷号	7 期号:34 页码:20789-20794
ISSN号	2046-2069
DOI	10.1039/c7ra02306e
文献子类	Article
英文摘要	Despite its 3D porous structure, the pharmaceutical applications of cyclodextrin based cross-linked polymers are limited due to their structural irregularities. To address this issue, a template-directed strategy is used to obtain cubic micro and nano cyclodextrin cross-linked polymer (CD-cubes) from cyclodextrin metal organic frameworks in this study. The well-organized gamma-CDs in MOFs were crosslinked by diphenyl carbonate by a facile single step chemical reaction. Scanning electron microscopy and X-ray diffraction analysis revealed the almost perfect cubic shapes of the particles with a disordered internal structure. Contrarily to the non-crosslinked materials which immediately dissolved in water, the CD-cubes were remarkably stable after extensive washing with water. The CD-cubes possessed a mesoporous structure with pore size in the range of 2-4 nm and showed much higher BET surface and 8 times higher adsorption capacity for doxorubicin as compared to conventional cyclodextrin-sponges.
资助项目	National Natural Science Foundation of China[81430087] ; [ANR-14-CE08-0017]
WOS关键词	METAL-ORGANIC FRAMEWORKS ; NANOSPONGES ; SPECTROSCOPY ; STABILITY ; DELIVERY
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000399722300011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275723]
专题	药物制剂研究中心
通讯作者	Gref, Ruxandra; Zhang, Jiwen
作者单位	1.Univ Paris Sud, UMR CNRS 8214, Univ Paris Saclay, Inst Sci Mol Orsay, F-91400 Orsay, France; 2.Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China; 3.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Singh, Vikramjeet,Guo, Tao,Wu, Li,et al. Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload[J]. RSC ADVANCES,2017,7(34):20789-20794.
APA	Singh, Vikramjeet.,Guo, Tao.,Wu, Li.,Xu, Jianghui.,Liu, Botao.,...&Zhang, Jiwen.(2017).Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload.RSC ADVANCES,7(34),20789-20794.
MLA	Singh, Vikramjeet,et al."Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload".RSC ADVANCES 7.34(2017):20789-20794.