A comparison report of three advanced methods for drug-cyclodextrin interaction measurements

doi:10.1016/j.jpba.2016.11.037

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	A comparison report of three advanced methods for drug-cyclodextrin interaction measurements
	Singh, Vikramjeet 3; He, Yaping 3; Wang, Caifen 1,3; Xu, Jianghui 3; Xu, Xiaonan 3,4; Li, Haiyan3 ; Singh, Parbeen 3; York, Peter 2,3; Sun, Lixin 4; Zhang, Jiwen1,3
刊名	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
	2017-02-05
卷号	134 页码:252-258
关键词	Drug-cyclodextrins interactions High performance affinity chromatography Surface plasmon resonance Surface plasmon resonance imaging Kinetic constants Sparingly soluble drugs
ISSN号	0731-7085
DOI	10.1016/j.jpba.2016.11.037
文献子类	Article
英文摘要	Three advanced methods, high performance affinity chromatography (HPAC), surface plasmon resonance (SPR) and surface plasmon resonance imaging (SPRi) were compared and evaluated for determining the drug-cyclodextrin (CD) interactions herein. In total, 18 sparingly soluble drugs were selected for this comparative study. The three methods share a unique connection in the working principles and strategies. The same strategies of CD fixation onto solid phase were used in HPAC and SPR for the measurements, whereas, the SPR and SPRi share identical working principles. However, whilst these relationships are evident, no strong correlation was found between kinetic constants obtained from the three methods: Four drugs, namely, prednisolone, pseudolaric acid B, diazepam and gramisetron failed to show any response on SPR, whereas, the kinetics parameters from SPRi and HPAC were successfully measured. From a comparative review of all the kinetic data, random results without any trends were observed (ka, kd and K-A) regardless of the relationships between the three methods: It is apparent that the measurement conditions (volume, flow rate, buffers), non-specific adsorption and experimental procedures had a strong impact on the generated data. The relative advantages and limitations of each method are critically presented on the basis of generated data. This comparative study provides a basis to further upgrade these techniques for confident measurement of drug-CDs interactions. (C) 2016 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[81430087] ; National Natural Science Foundation of China[81573392] ; National Science and Technology Major Project[2013ZX09402103]
WOS关键词	SURFACE-PLASMON RESONANCE ; FLUORESCENCE CORRELATION SPECTROSCOPY ; BETA-CYCLODEXTRIN ; BIOLOGICAL-MEMBRANES ; BIACORE(R) SYSTEM ; COMPLEXES ; DYNAMICS ; BINDING
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000392909900032
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275635]
专题	药物制剂研究中心
通讯作者	Sun, Lixin; Zhang, Jiwen
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut Anal, 103 Wenhua Rd, Shenyang 110016, Peoples R China;
推荐引用方式 GB/T 7714	Singh, Vikramjeet,He, Yaping,Wang, Caifen,et al. A comparison report of three advanced methods for drug-cyclodextrin interaction measurements[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2017,134:252-258.
APA	Singh, Vikramjeet.,He, Yaping.,Wang, Caifen.,Xu, Jianghui.,Xu, Xiaonan.,...&Zhang, Jiwen.(2017).A comparison report of three advanced methods for drug-cyclodextrin interaction measurements.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,134,252-258.
MLA	Singh, Vikramjeet,et al."A comparison report of three advanced methods for drug-cyclodextrin interaction measurements".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 134(2017):252-258.