Absorption-enhancing mechanisms and advances of polymer-based supersaturated drug delivery system

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Absorption-enhancing mechanisms and advances of polymer-based supersaturated drug delivery system
	Gong Shuang 5; Zhu Chunliu4 ; Ding Jinsong 5; Gan Yong2
刊名	Acta Pharmaceutica Sinica
	2018
卷号	53 期号:8 页码:1310-1317
关键词	polymer supersaturated drug delivery system anti-precipitation oral absorption
ISSN号	0513-4870
其他题名	聚合物型过饱和给药系统的促吸收机制及研究进展
文献子类	Review
英文摘要	Supersaturated drug delivery systems (SDDS) are defined as systems that are able to generate and maintain a sustained drug supersaturation in the gastrointestinal tract, facilitating the oral absorption of drugs with poor water solubility. Supersaturated drug solution is generated from a higher energy form of the drug or rapid dissolution through various formulation options. However, supersaturated solution is a thermodynamically unstable system that can easily lead to drug precipitation, missing the aim of improving the absorption. Therefore, maintenance of the supersaturated state is essential for the development of SDDS. Polymer-based SDDS take polymers as the precipitation inhibitor,which can effectively prevent the precipitation of drugs, generating an excellent effect on maintenance of the stability of supersaturated solution. However, different polymers have distinct anti-precipitation ability, and the mechanisms of such activity supported by the polymer remain unrevealed. In this review, we summarize the research advances in the absorption-enhancing mechanisms and in vitro evaluations of polymers-based SDDS. This review provides a reference for the design of rational SDDS.
资助项目	国家自然科学基金资助项目[00000000] ; 上海市国际科技合作基金资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:6301232
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269163]
专题	药物制剂研究中心
通讯作者	Gan Yong
作者单位	1.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 3.Shanghai; 4.Shanghai Institute of Materia Medica, Chinese Academy of Sciences; 5.Xiangya School of Pharmaceutical Science, Central South University, Changsha, Hunan 410000, China.;
推荐引用方式 GB/T 7714	Gong Shuang,Zhu Chunliu,Ding Jinsong,et al. Absorption-enhancing mechanisms and advances of polymer-based supersaturated drug delivery system[J]. Acta Pharmaceutica Sinica,2018,53(8):1310-1317.
APA	Gong Shuang,Zhu Chunliu,Ding Jinsong,&Gan Yong.(2018).Absorption-enhancing mechanisms and advances of polymer-based supersaturated drug delivery system.Acta Pharmaceutica Sinica,53(8),1310-1317.
MLA	Gong Shuang,et al."Absorption-enhancing mechanisms and advances of polymer-based supersaturated drug delivery system".Acta Pharmaceutica Sinica 53.8(2018):1310-1317.