Three Dimension Reconstruction Tells More about the Release Kinetics of the Controlled/Sustained Release Tablets of Felodipine

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Three Dimension Reconstruction Tells More about the Release Kinetics of the Controlled/Sustained Release Tablets of Felodipine
	Zhang JW(张继稳)
	2011-09-19
关键词	controlled release system sustained release system release kinetics synchrotron radiation X-ray computed microtomography three dimensional reconstruction fractal dimension analysis
页码	1
英文摘要	Purpose:i) to visualize the internal structure of the tablet core for two sustained-release drug delivery systems of felodipine(monolith osmotic pump tablets and hydrophilic matrix tablets) via synchrotron radiation X-ray computed microtomography during the drug release process,ii) to correlate the 3D steric data quantitatively with the remaining percentages of the drug in the tablet core;(iii) to elucidate the drug release mechanism of the sustained-release systems through internal 3D steric data analysis and fractal dimension analysis. Methods:The surface areas,three dimensional parameters and the fractal dimension of the tablet cores were calculated based on the three dimensional reconstruction of the images.At different stages of the drug release process,the surface morphology,the hydration,the swelling,and the structure changing of the tablet,were visualized from the two dimensional monochrome X-ray images. Results:For the osmotic pump tablet,the three dimensional volumes of the remaining tablet core and the fractal dimension correlated well with the percentages of felodipine.The three dimensional surface area almost unchanged during the drug release process,which clearly demonstrated the intrinsic drug release mechanism of the osmotic drug delivery system.For the hydrophilic matrix tablet,a quantitative relationship was established between drug release kinetics and the steric parameters,including Surface(hydration),Surface(core) and SSurface(core). Conclusions:The synchrotron radiation X-ray computed microtomography,with rapid acquisition,high intensity and micro-scale spatial resolution,was found to be a useful tool for the quantitative elucidation of the intrinsic drug release kinetics.X-ray computed microtomography can be considered as a new and complimentary analytical tool to standard compendial pharmaceutical tests for quality control of osmotic drug delivery systems.
会议录	第二届亚洲药物制剂科学与技术研讨会——第二届《亚洲药物制剂科学杂志》编委会扩大会议论文集
文献子类	Article
语种	英语
内容类型	会议论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267246]
专题	药物制剂研究中心
作者单位	中国科学院上海药物研究所,药物制剂研究中心,上海 201203, 中国.
推荐引用方式 GB/T 7714	Zhang JW. Three Dimension Reconstruction Tells More about the Release Kinetics of the Controlled/Sustained Release Tablets of Felodipine[C]. 见:.