Cocktail Strategy Based on Spatio-Temporally Controlled Nano Device Improves Therapy of Breast Cancer

doi:10.1002/adma.201806202

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	Cocktail Strategy Based on Spatio-Temporally Controlled Nano Device Improves Therapy of Breast Cancer
	Lang, Tianqun 1,2; Liu, Yiran 2,4; Zheng, Zhong 2,3; Ran, Wei 1,2; Zhai, Yihui 1,2; Yin, Qi1,2 ; Zhang, Pengcheng1,2 ; Li, Yaping1,2
刊名	Advanced Materials
	2018
ISSN号	09359648
DOI	10.1002/adma.201806202
文献子类	Article
英文摘要	Metastatic breast cancer may be resistant to chemo-immunotherapy due to the existence of cancer stem cells (CSC). And the control of particle size and drug release of a drug carrier for multidrug combination is a key issue influencing therapy effect. Here, a cocktail strategy is reported, in which chemotherapy against both bulk tumor cells and CSC and immune checkpoint blockade therapy are intergraded into one drug delivery system. The chemotherapeutic agent paclitaxel (PTX), the anti-CSC agent thioridazine (THZ), and the PD-1/PD-L1 inhibitor HY19991 (HY) are all incorporated into an enzyme/pH dual-sensitive nanoparticle with a micelle-liposome double-layer structure. The particle size shrinks when the nanoparticle transfers from circulation to tumor tissues, favoring both pharmacokinetics and cellular uptake, meanwhile achieving sequential drug release where needed. This nano device, named PM@THL, increases the intratumoral drug concentrations in mice and exhibits significant anticancer efficacy, with tumor inhibiting rate of 93.45% and lung metastasis suppression rate of 97.64%. It also declines the proportion of CSC and enhances the T cells infiltration in tumor tissues, thus prolongs the survival of mice. The cocktail therapy based on the spatio-temporally controlled nano device will be a promising strategy for treating breast cancer.
语种	英语
出版者	Wiley-VCH Verlag
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266970]
专题	药物制剂研究中心
通讯作者	Yin, Qi
作者单位	1.School of Pharmacy, University of Chinese Academy of Sciences, Beijing; 100049, China; 2.State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai; 201203, China; 3.College of Life Sciences, Jilin University, Changchun; 130012, China 4.Nano Science and Technology Institute, University of Science and Technology of China, Suzhou; 215123, China;
推荐引用方式 GB/T 7714	Lang, Tianqun,Liu, Yiran,Zheng, Zhong,et al. Cocktail Strategy Based on Spatio-Temporally Controlled Nano Device Improves Therapy of Breast Cancer[J]. Advanced Materials,2018.
APA	Lang, Tianqun.,Liu, Yiran.,Zheng, Zhong.,Ran, Wei.,Zhai, Yihui.,...&Li, Yaping.(2018).Cocktail Strategy Based on Spatio-Temporally Controlled Nano Device Improves Therapy of Breast Cancer.Advanced Materials.
MLA	Lang, Tianqun,et al."Cocktail Strategy Based on Spatio-Temporally Controlled Nano Device Improves Therapy of Breast Cancer".Advanced Materials (2018).