| Structure and Cytotoxicity of Diterpenoids from Isodon eriocalyx | |
Li, Xiao-Nian3; Pu, Jian-Xin3; Du, Xue3; Lou, Li-Guang1 ; Li, Li-Mei3; Huang, Sheng-Xiong3; Zhao, Bo2; Zhang, Mei2; He, Fei3; Luo, Xiao3
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 2010-11 | |
| 卷号 | 73期号:11页码:1803-1809 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np1004328 |
| 文献子类 | Article |
| 英文摘要 | A new ent-atisanoid, eriocatisin A (1), six new ent-abietanoids, eriocasins B-E (2-4, 7), 3-acetyleriocasin C (5), and 3 beta-acetoxyeriocasin D (6), and seven new ent-kauranoids, maoesins A-F (8, 10-14) and 3 alpha-acetoxy-maoesin A (9), together with 21 known compounds, were isolated from the aerial parts of Isodon eriocalyx. The structures of 1-14 were determined by spectroscopic data interpretation. All compounds isolated were evaluated for their in vitro growth inhibitory activity against the HT-29, BEL-7402, and SK-OV-3 human cancer cell lines. Compounds 17, 18, and 20 showed inhibitory effects for all three tumor cell lines used, with IC50 values in the range 2.1-7.3 mu M. |
| 资助项目 | NSFC[30772637] ; NSFC[30830119] ; NSFC-Joint Foundation of Yunnan Province[U0832602] ; Major State Basic Research Development Program of China[2009CB522300] ; Major State Basic Research Development Program of China[2009CB940900] ; Natural Science Foundation of Yunnan Province[2008CD162] ; Science and Technology Program of Yunnan Province[2008IF010] |
| WOS关键词 | ENT-KAURENE DITERPENOIDS ; RUBESCENS VAR.-TAIHANGENSIS ; RABDOSIA-ERIOCALYX ; ABSOLUTE CONFIGURATION ; ABIETANE DITERPENOIDS ; KAURANE DITERPENOIDS ; KAPPA-B ; A-C ; TERPENOIDS ; SKELETON |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000284559100011 |
| 内容类型 | 期刊论文 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278742]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Pu, Jian-Xin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 2.Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 610075, Sichuan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Xiao-Nian,Pu, Jian-Xin,Du, Xue,et al. Structure and Cytotoxicity of Diterpenoids from Isodon eriocalyx[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(11):1803-1809. |
| APA | Li, Xiao-Nian.,Pu, Jian-Xin.,Du, Xue.,Lou, Li-Guang.,Li, Li-Mei.,...&Sun, Han-Dong.(2010).Structure and Cytotoxicity of Diterpenoids from Isodon eriocalyx.JOURNAL OF NATURAL PRODUCTS,73(11),1803-1809. |
| MLA | Li, Xiao-Nian,et al."Structure and Cytotoxicity of Diterpenoids from Isodon eriocalyx".JOURNAL OF NATURAL PRODUCTS 73.11(2010):1803-1809. |
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