Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases

doi:10.1021/np200831c

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases
	Mpetga, James D. Simo 1,2; Shen, Yu 3; Tane, Pierre 2; Li, Shi-Fei 1; He, Hong-Ping 1; Wabo, Hippolyte K.2; Tene, Mathieu 2; Leng, Ying3 ; Hao, Xiao-Jiang 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2012-04
卷号	75 期号:4 页码:599-604
ISSN号	0163-3864
DOI	10.1021/np200831c
文献子类	Article
英文摘要	Five new triterpenoids, caloncobic acids A and B (1 and 2), caloncobalactones A and B (3 and 4), and glaucalactone (5), along with the known compounds 3 beta,21 beta-dihydroxy-30-nor-(D:A)-friedo-olean-20(29)-en-27-oic acid (6) and acetyltrichadenic acid B (7), were isolated from the leaves of Caloncoba glauca. The structures of 1-5 were elucidated using spectroscopic methods. Compounds 1-7 were evaluated for their inhibitory activities against two isozymes of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1 and 11 beta-HSD2). Compounds 1 and 2 exhibited strong inhibitory activities against mouse (EC50 132 and 13 nM) and human (EC50 105 and 72 nM) 11 beta-HSD1.
资助项目	University of Dschang[00000000] ; Chinese Academy of Sciences (CAS)[00000000] ; Academy of Sciences for the Developing World (TWAS)[00000000]
WOS关键词	ELLIPTICA HAND-MAZZ ; STEM BARK ; LYOFOLIC ACID ; CONSTITUENTS ; GLYCOSIDES ; GLUCOSIDE
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000303220500012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278128]
专题	药理学第一研究室
通讯作者	Leng, Ying
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China; 2.Univ Dschang, Dept Chem, Lab Nat Prod Chem, Dschang, Cameroon 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Mpetga, James D. Simo,Shen, Yu,Tane, Pierre,et al. Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(4):599-604.
APA	Mpetga, James D. Simo.,Shen, Yu.,Tane, Pierre.,Li, Shi-Fei.,He, Hong-Ping.,...&Hao, Xiao-Jiang.(2012).Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases.JOURNAL OF NATURAL PRODUCTS,75(4),599-604.
MLA	Mpetga, James D. Simo,et al."Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases".JOURNAL OF NATURAL PRODUCTS 75.4(2012):599-604.