Synthesis and cytotoxicity of platinum(III) complexes of a physiologically active carrier histamine

doi:10.1002/ardp.200700155

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Synthesis and cytotoxicity of platinum(III) complexes of a physiologically active carrier histamine
	Chen, Xi-Zhu 2; Ye, Oing-Song 2; Lou, Li-Guang1 ; Xie, Ming-Jin 2; Liu, Wei-Ping 2; Yu, Yao 2; Hou, Shu-Qian 2
刊名	ARCHIV DER PHARMAZIE
	2008-02
卷号	341 期号:2 页码:132-136
关键词	antitumor activity histamine platinum (II) complexes synthesis structure
ISSN号	0365-6233
DOI	10.1002/ardp.200700155
文献子类	Article
英文摘要	A series of novel platinum(II) complexes involving a physiologically active carrier histamine as the carrier, cis-[Pt(histamine)X-2] (X-2 = 2Cl(-), oxalate, malonate, 1,1-cyclobutanedicarboxylate (CBDCA), 3-hydroxy-1,1-cyclobutanedicarboxylate (HO-CBDCA)), have been synthesized and characterized by elemental analysis and spectroscopic data along with X-ray crystal structure for a representative complex cis-[Pt(histamine)Cl-2]. The cytotoxicity of the complexes has also been assessed in the human cancer cell lines A549/ATCC, HT-29, and LNcap. One complex, cis-[Pt(histamine)Cl-2], is more active than carboplatin against both the sensitive and resistant cells.
WOS关键词	ANTITUMOR AGENTS ; CISPLATIN ; PERSPECTIVES ; RESISTANCE ; DESIGN ; DRUGS ; ION
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000253436100007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272985]
专题	药理学第一研究室
通讯作者	Liu, Wei-Ping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Kunming Inst Precious Met, Platinum Based Drug Lab, Kunming 650106, Peoples R China;
推荐引用方式 GB/T 7714	Chen, Xi-Zhu,Ye, Oing-Song,Lou, Li-Guang,et al. Synthesis and cytotoxicity of platinum(III) complexes of a physiologically active carrier histamine[J]. ARCHIV DER PHARMAZIE,2008,341(2):132-136.
APA	Chen, Xi-Zhu.,Ye, Oing-Song.,Lou, Li-Guang.,Xie, Ming-Jin.,Liu, Wei-Ping.,...&Hou, Shu-Qian.(2008).Synthesis and cytotoxicity of platinum(III) complexes of a physiologically active carrier histamine.ARCHIV DER PHARMAZIE,341(2),132-136.
MLA	Chen, Xi-Zhu,et al."Synthesis and cytotoxicity of platinum(III) complexes of a physiologically active carrier histamine".ARCHIV DER PHARMAZIE 341.2(2008):132-136.