Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-K-2 N,N '] platinum(II) complexes

doi:10.1016/j.jinorgbio.2008.07.003

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	Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-K-2 N,N '] platinum(II) complexes
	Liu, Weiping 2; Chen, Xizhu 2; Xie, Mingjin 3; Lou, Liguang1 ; Ye, Qingsong 2; Yu, Yao 2; Hou, Shuqian 2
刊名	JOURNAL OF INORGANIC BIOCHEMISTRY
	2008-10
卷号	102 期号:10 页码:1942-1946
关键词	platinum complexes peripheral functional group HO- synthesis structure anti-tumor
ISSN号	0162-0134
DOI	10.1016/j.jinorgbio.2008.07.003
文献子类	Article
英文摘要	A series of novel platinum(II) complexes involving a carrier with HO- peripheral functional group, 2-hydroxy-1,3-propanediamine (HO-pda), cis-[Pt(HO-dpa)X-2] (X-2 = 2Cl(-) (1), C2O42- (2), malonate (3), 1,1-cyclobutane dicarboxylate (CBDCA) (4), 3-hydroxy-1,1-cyclobutanedicarboxylate (HO-CBDCA) (5)), have been synthesized and characterized by elemental analysis and spectroscopic data along with X-ray diffraction for three representative complexes 1, 4 and 5. The Pt(II) is in a square planar environment and is coordinated in cis position by a chelating HO-pda and 2Cl(-) for 1 and CBDCA for 4 and 5. Pt-N, Pt-Cl and Pt-O distances and coordinate bond angles of N-Pt-N, Cl-Pt-Cl and O-Pt-O are in the normal range. There are two independent molecules in the asymmetric unit of 5, held together by intermolecular hydrogen bonded chain. All the complexes show significant cytotoxicity on the sensitive cell lines SGC-7901, LNcap and A549, and are more active than carboplatin. 4 is also found to be active against the resistant cell A549/ATCC, which suggests that it has less cross-resistance with cisplatin than carboplatin. Moreover 4 shows much greater inhibition of tumor growth than carboplatin in S180-bearing mice, and is therefore worthy of further development as a potential anti-tumor platinum drug. (c) 2008 Elsevier Inc. All rights reserved.
资助项目	Yunnan Provincial Science Foundation of PR China[2006C0070M] ; Yunnan Provincial Science Foundation of PR China[2008C002M]
WOS关键词	DESIGN STRATEGIES ; CARRIER ; AGENTS ; CYTOTOXICITY ; PERSPECTIVES
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000259385700013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272794]
专题	药理学第一研究室
通讯作者	Liu, Weiping
作者单位	1.CAS, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Kunming Inst Precious Met, Platinum Based Drug Lab, Kunming 650106, Peoples R China; 3.Yunan Univ, Sch Chem, Yunan 650031, Peoples R China;
推荐引用方式 GB/T 7714	Liu, Weiping,Chen, Xizhu,Xie, Mingjin,et al. Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-K-2 N,N '] platinum(II) complexes[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2008,102(10):1942-1946.
APA	Liu, Weiping.,Chen, Xizhu.,Xie, Mingjin.,Lou, Liguang.,Ye, Qingsong.,...&Hou, Shuqian.(2008).Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-K-2 N,N '] platinum(II) complexes.JOURNAL OF INORGANIC BIOCHEMISTRY,102(10),1942-1946.
MLA	Liu, Weiping,et al."Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-K-2 N,N '] platinum(II) complexes".JOURNAL OF INORGANIC BIOCHEMISTRY 102.10(2008):1942-1946.