Pharmacokinetics of R-(-)ondansetron compared with that of S-(-)ondansetron in rats using an LC-MS/MS method

doi:10.1002/bmc.4426

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	Pharmacokinetics of R-(-)ondansetron compared with that of S-(-)ondansetron in rats using an LC-MS/MS method
	Duan, Mingyu 2; Zhao, Qi 2; Zhong, Dafang1 ; Yuan, Yue 2
刊名	Biomedical chromatography : BMC
	2018-11-08
页码	e4426
ISSN号	1099-0801
DOI	10.1002/bmc.4426
文献子类	Article
英文摘要	The pharmacokinetics of R-(-)ondansetron (R-ond) compared with that of S-(-)ondansetron (S-ond) was studied in rats. R-ond and S-ond were injected intravenously into rats at a dose of 2.0 mg/kg. The stability of ondansetron enantiomers in rat was determined by chiral HPLC, and the concentrations of R-ond and S-ond in plasma were determined by an LC/MS/MS method. The pharmacokinetic parameters were calculated and analyzed statistically using the t-test. The enantiomer inversions between R-ond and S-ond did not occur in rat. The pharmacokinetic parameters (t , AUC, MRT, CL) of R-ond and S-ond differed significantly. The concentration in plasma of the R/S-enantiomeric ratio reached a maximum value of 9.5 at 4.0 h post-dose. The pharmacokinetics of R-ond and S-ond are stereoselective in rat, which indicates substantial stereoselectivity in the disposition of ondansetron enantiomers in rat. R-ond has more potential than S-ond to be developed as a single enantiomer drug.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266337]
专题	上海药物代谢研究中心
作者单位	1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China 2.School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, Shenyang, China;
推荐引用方式 GB/T 7714	Duan, Mingyu,Zhao, Qi,Zhong, Dafang,et al. Pharmacokinetics of R-(-)ondansetron compared with that of S-(-)ondansetron in rats using an LC-MS/MS method[J]. Biomedical chromatography : BMC,2018:e4426.
APA	Duan, Mingyu,Zhao, Qi,Zhong, Dafang,&Yuan, Yue.(2018).Pharmacokinetics of R-(-)ondansetron compared with that of S-(-)ondansetron in rats using an LC-MS/MS method.Biomedical chromatography : BMC,e4426.
MLA	Duan, Mingyu,et al."Pharmacokinetics of R-(-)ondansetron compared with that of S-(-)ondansetron in rats using an LC-MS/MS method".Biomedical chromatography : BMC (2018):e4426.