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	Ophiorrhines A and B, Two Immunosuppressive Monoterpenoid Indole Alkaloids from Ophiorrhiza japonica
	Feng, Tao2; Duan, Kai-Ting2; He, Shi-Jun1; Wu, Bin2; Zheng, Yong-Sheng2; Ai, Hong-Lian2; Li, Zheng-Hui2; He, Juan2; Zuo, Jian-Ping1; Liu, Ji-Kai2
刊名	Organic letters
	2018-12-10
ISSN号	1523-7052
DOI	10.1021/acs.orglett.8b03489
文献子类	Article
英文摘要	Two monoterpenoid indole alkaloids, ophiorrhines A (1) and B (2), were obtained from plant Ophiorrhiza japonica BI. Their structures were elucidated by extensive spectroscopic methods and single crystal X-ray diffraction. Compounds 1 and 2 possess a novel spirocyclic ring system. Its biosynthesis pathway is proposed. Compound 2 exhibits potent inhibitory activity against concanavalin A (Con A) induced T cell proliferation and lipopolysaccharide (LPS) induced B lymphocyte cell proliferation with IC values 13.3 and 7.5 μM, respectively. Compound 1 exhibits significant inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC value 18.6 μM.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266318]
专题	药理学第一研究室
作者单位	1.State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China 2.School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan 430074 , China;
推荐引用方式 GB/T 7714	Feng, Tao,Duan, Kai-Ting,He, Shi-Jun,et al. Ophiorrhines A and B, Two Immunosuppressive Monoterpenoid Indole Alkaloids from Ophiorrhiza japonica[J]. Organic letters,2018.
APA	Feng, Tao.,Duan, Kai-Ting.,He, Shi-Jun.,Wu, Bin.,Zheng, Yong-Sheng.,...&Liu, Ji-Kai.(2018).Ophiorrhines A and B, Two Immunosuppressive Monoterpenoid Indole Alkaloids from Ophiorrhiza japonica.Organic letters.
MLA	Feng, Tao,et al."Ophiorrhines A and B, Two Immunosuppressive Monoterpenoid Indole Alkaloids from Ophiorrhiza japonica".Organic letters (2018).

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