A Novel Strategy for Preparing Glycopeptide Molecular Probe Using Fluorous Technology

doi:10.2174/0929866521666140626105814

	A Novel Strategy for Preparing Glycopeptide Molecular Probe Using Fluorous Technology
	Liu, Zhiguo 2; Rong, Pengfei 2; Gu, Xiangying 3; Yu, Lun 2; Chen, Guohua 3; Chen, Yue-Lei4 ; Zhang, Shuai 1; Shen, Jingkang 4; Zeng, Wenbin 2
刊名	PROTEIN AND PEPTIDE LETTERS
	2014
卷号	21 期号:10 页码:1011-1016
关键词	Fluorous technology glycopeptide iodination molecular probe
ISSN号	0929-8665
DOI	10.2174/0929866521666140626105814
文献子类	Article
英文摘要	A novel and convenient strategy for iodine labeled glycopeptide molecular probe and purification was developed. The fluorine rich bi-functional coupling agent, 4-tris(2-perfluorohexylethyl)stannylbenzoate succinimidyl ester, was successfully synthesized via 5 steps starting from the fluorous Grignard reagent. It was purified by a simple and fast isolation using perfluorinated hexanes (FC-72). The "cold" iodine labeled yield for the coupling agent was as high as 92% within 15 min. The iodine-labeled product was only in organic fractions as we expected. It was shown that there was only one major peak in organic fractions according to HPLC. Finally, the iodine-labeled coupling agent was applied to label glycopeptide and afforded a high yield of 87% within 30 min.
资助项目	New Century Excellent Talents Project[NCET-10-0800] ; Fundamental Research Funds for the Central Universities, Hunan Provincial Natural Science Foundation of China[12JJ1012] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2012ZX09301001]
WOS关键词	SOLID-PHASE ; ORGANIC-SYNTHESIS ; RADIOPHARMACEUTICALS ; SYSTEM
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000341871000007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277267]
专题	药物化学研究室
通讯作者	Zeng, Wenbin
作者单位	1.Cent S Univ, Xiangya Hosp, Dept Otolaryngol, Changsha 410008, Hunan, Peoples R China 2.Cent S Univ, Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China;
推荐引用方式 GB/T 7714	Liu, Zhiguo,Rong, Pengfei,Gu, Xiangying,et al. A Novel Strategy for Preparing Glycopeptide Molecular Probe Using Fluorous Technology[J]. PROTEIN AND PEPTIDE LETTERS,2014,21(10):1011-1016.
APA	Liu, Zhiguo.,Rong, Pengfei.,Gu, Xiangying.,Yu, Lun.,Chen, Guohua.,...&Zeng, Wenbin.(2014).A Novel Strategy for Preparing Glycopeptide Molecular Probe Using Fluorous Technology.PROTEIN AND PEPTIDE LETTERS,21(10),1011-1016.
MLA	Liu, Zhiguo,et al."A Novel Strategy for Preparing Glycopeptide Molecular Probe Using Fluorous Technology".PROTEIN AND PEPTIDE LETTERS 21.10(2014):1011-1016.