Inhibitory effects of ginkgolides on nitric oxide production in neonatal rat microglia in vitro

	Inhibitory effects of ginkgolides on nitric oxide production in neonatal rat microglia in vitro
	Du, ZY; Li, XY
刊名	ACTA PHARMACOLOGICA SINICA
	1998-09
卷号	19 期号:5 页码:467-470
关键词	ginkgolides platelet-activating factor nitroarginine nitric oxide microglia lipopolysaccharides cultured cells apafant
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To study the effects of ginkgolide A (GA) and B (GB), apafant (Apa), and N omega-nitro-L-arginine (L-NA) on nitric oxide (NO) production in cultured neonatal rat microglia. METHODS: NO concentration was represented by nitrite which was determined by Griess reaction. RESULTS: In resting microglia, no inhibitory effects of GA, GB, and Apa were observed. L-NA inhibited NO production, its IC50 value (95 % confidence limits) being 3.4 (0.8-14.9) mu mol . L-1 GA, GB, and L-NA inhibited NO production in LSS-stimulated microglia, and their IC50 values (95 % confidence limits) were 5.7 (1.8 - 18.1), 1.1 (0.3 - 4.4), and 0.5 (0.1 - 2.8) mu mol . L-1, respectively. Apa did not inhibit NO production. CONCLUSION: GA and GB inhibited NO production in LPS-stimulated microglia.
WOS关键词	ANTAGONISTS ; BRAIN ; INJURY ; CELLS
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000075784800018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274810]
专题	药物化学研究室药理学第三研究室药物制剂研究中心
通讯作者	Li, XY
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Du, ZY,Li, XY. Inhibitory effects of ginkgolides on nitric oxide production in neonatal rat microglia in vitro[J]. ACTA PHARMACOLOGICA SINICA,1998,19(5):467-470.
APA	Du, ZY,&Li, XY.(1998).Inhibitory effects of ginkgolides on nitric oxide production in neonatal rat microglia in vitro.ACTA PHARMACOLOGICA SINICA,19(5),467-470.
MLA	Du, ZY,et al."Inhibitory effects of ginkgolides on nitric oxide production in neonatal rat microglia in vitro".ACTA PHARMACOLOGICA SINICA 19.5(1998):467-470.