Recent advances towards the discovery of dopamine receptor ligands

doi:10.1517/13543776.16.5.587

	Recent advances towards the discovery of dopamine receptor ligands
	Zhang, Ao; Kan, Ying; Li, Fuying
刊名	EXPERT OPINION ON THERAPEUTIC PATENTS
	2006-05
卷号	16 期号:5 页码:587-630
关键词	atypical antipsychotic brain disorder CNS dopamine dopamine agonist dopamine antagonist dopamine receptor Parkinson's disease schizophrenia serotonin
ISSN号	1354-3776
DOI	10.1517/13543776.16.5.587
文献子类	Review
英文摘要	Dopamine is a key regulator in the CNS, contributing importantly to functions of arousal and attention, initiation of movement, perception, motivation and emotion. its imbalance has been implicated in the pathophysiology, and more clearly in the pharmacology, of a number of neurobehavioural disorders, including Parkinson's disease, schizophrenia, mania and depression, alcohol and drug abuse, as well as attention and eating disorders. Five major dopamine receptor subtypes (D1 - D5) have been identified, with distinct differences in their genes and peptide composition, molecular functions and neuropharmacology. These receptors represent the rational targets for the treatment of a large number of neurological and psychiatric disorders. In recent years, substantial efforts have addressed the most recently described dopamine receptor types, particularly types D3, D4 and D5, although most research involves the longer-known D1 and D2 dopamine receptors. Current pharmacological efforts in medicinal chemistry and neuropharmacology include the development of D1 full agonists and D2 partial agonists, as well as agents with dopaminergic activity combined with effects at CNS serotonergic, muscarinic, adrenergic and histaminic receptors. This review provides an overview of the recent patent literature during 2003 - 2005 on the development of therapeutic agents, mainly targeting the five dopamine receptors.
WOS关键词	ATYPICAL ANTIPSYCHOTIC AGENTS ; GAMMA-S BINDING ; PARKINSONS-DISEASE ; DRUG-TREATMENT ; WEIGHT-GAIN ; HUMAN-BRAIN ; SCHIZOPHRENIA ; AGONIST ; DERIVATIVES ; ANTAGONISTS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000237502300003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273606]
专题	药物化学研究室
通讯作者	Zhang, Ao
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Synthet Organ & Med Chem Lab, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ao,Kan, Ying,Li, Fuying. Recent advances towards the discovery of dopamine receptor ligands[J]. EXPERT OPINION ON THERAPEUTIC PATENTS,2006,16(5):587-630.
APA	Zhang, Ao,Kan, Ying,&Li, Fuying.(2006).Recent advances towards the discovery of dopamine receptor ligands.EXPERT OPINION ON THERAPEUTIC PATENTS,16(5),587-630.
MLA	Zhang, Ao,et al."Recent advances towards the discovery of dopamine receptor ligands".EXPERT OPINION ON THERAPEUTIC PATENTS 16.5(2006):587-630.