Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression

doi:10.1007/s12020-016-1203-3

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression
	Zhu, Jing-Jie 1,3; Huang, Jun-Shang 1,3; Wang, Ting 3; Ji, Jun 2; Hou, Ai-Jun 2; Wang, He-Yao3
刊名	ENDOCRINE
	2017-04
卷号	56 期号:1 页码:73-81
关键词	Sanggenol F Adipogenesis Adipokine PPAR gamma PTP1B Type 2 diabetes
ISSN号	1355-008X
DOI	10.1007/s12020-016-1203-3
文献子类	Article
英文摘要	Adipose tissue is not only a lipid storage site, but also a well-known endocrine organ. Dysfunction of adipose tissue is associated with irregular lipid metabolism, ectopic lipid accumulation and insulin resistance. It is proposed that modulating on adipose tissue is a reasonable way to ameliorate glucose and lipid metabolism. (+/-)-sanggenol F (SGF, purity > 98.5%) was synthesized as a racemic mixture of natural (+)-sanggenol F. In this study, SGF was found to promote adipocyte differentiation, enhance insulin sensitivity, and upregulate beneficial adipokines expression in 3T3-L1 cells. Furthermore, in vivo study showed that treatment with SGF for 4 weeks improved glucose metabolism, by decreasing fasting blood glucose and enhancing insulin sensitivity. It also improved lipid metabolism, with reduced serum lipid level and ameliorated hepatic steatosis in db/db mice. During the process of target finding, we found that SGF had multiple activities of protein tyrosine phosphatase 1B inhibition, peroxisome proliferator-activated receptor gamma and peroxisome proliferator-activated receptor alpha agonism. These results showed the potential of SGF as a candidate for the therapy of type 2 diabetes.
资助项目	National Natural Science Foundation of China[81222045] ; National Natural Science Foundation of China[21172044] ; National Natural Science Foundation of China[81503124] ; National Natural Science Foundation of China[81473262] ; Science and Technology Commission of Shanghai Municipality Project[14ZR1447700] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120162025] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120164014] ; Shanghai Municipal Education Commission[12SG02] ; Shanghai Education Development Foundation[12SG02]
WOS关键词	ACTIVATED PROTEIN-KINASE ; PPAR-GAMMA ; ISOPRENYLATED FLAVONOIDS ; INSULIN SENSITIVITY ; GLUCOSE ; ADIPOGENESIS ; LIVER ; MICE ; RESISTANCE ; OXIDATION
WOS研究方向	Endocrinology & Metabolism
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000398948900011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272721]
专题	药理学第三研究室
通讯作者	Hou, Ai-Jun; Wang, He-Yao
作者单位	1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.Fudan Univ, Sch Pharm, Dept Pharmacognosy, 826 Zhang Heng Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zhu, Jing-Jie,Huang, Jun-Shang,Wang, Ting,et al. Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression[J]. ENDOCRINE,2017,56(1):73-81.
APA	Zhu, Jing-Jie,Huang, Jun-Shang,Wang, Ting,Ji, Jun,Hou, Ai-Jun,&Wang, He-Yao.(2017).Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression.ENDOCRINE,56(1),73-81.
MLA	Zhu, Jing-Jie,et al."Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression".ENDOCRINE 56.1(2017):73-81.