A potential target for diabetes and atherosclerosis:FABP4(aP2)

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	A potential target for diabetes and atherosclerosis:FABP4(aP2)
	YAN Gui-mi; ZHANG Xiao-dong; CAI Hai-yan; ZHU Wei-liang; WANG He-yao
刊名	Chinese Bulletin of Life Sciences
	2009
卷号	21 期号:2 页码:270-275
关键词	adipocyte fatty-acid-binding protein diabetes atherosclerosis drug target
ISSN号	1004-0374
其他题名	糖尿病和动脉粥样硬化的潜在靶标FABP4(aP2)
文献子类	Review
英文摘要	Adipocyte fatty-acid-binding protein (A-FABP/FABP4/aP2/ALBP), a member of the intracellular fatty acid binding proteins (FABPs), is primarily located in adipocytes and macrophages. It has been shown that loss of Fabp4 improved insulin resistance and ameliorated atherosclerosis in Fabp4 deficient mice. In addition, inhibitors of FABP4 reduced the size of atherosclerotic lesions and increased insulin sensitivity. Thus, FABP4 has been viewed as a potential therapeutic target in treatment of diabetes and atherosclerosis.
资助项目	"863"项目[00000000] ; 上海药物研究所基础研究项目[00000000]
WOS研究方向	Biochemistry & Molecular Biology ; General & Internal Medicine ; Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:3716193
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268017]
专题	药理学第三研究室
通讯作者	WANG He-yao
作者单位	Shanghai Institute of Materia Media, Chinese Academy of Science, Shanghai 201203, China.
推荐引用方式 GB/T 7714	YAN Gui-mi,ZHANG Xiao-dong,CAI Hai-yan,et al. A potential target for diabetes and atherosclerosis:FABP4(aP2)[J]. Chinese Bulletin of Life Sciences,2009,21(2):270-275.
APA	YAN Gui-mi,ZHANG Xiao-dong,CAI Hai-yan,ZHU Wei-liang,&WANG He-yao.(2009).A potential target for diabetes and atherosclerosis:FABP4(aP2).Chinese Bulletin of Life Sciences,21(2),270-275.
MLA	YAN Gui-mi,et al."A potential target for diabetes and atherosclerosis:FABP4(aP2)".Chinese Bulletin of Life Sciences 21.2(2009):270-275.