Interaction of the retinoic acid signaling pathway with spicule formation in the marine sponge Suberites domuncula through activation of bone morphogenetic protein-1

doi:10.1016/j.bbagen.2011.09.006

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	Interaction of the retinoic acid signaling pathway with spicule formation in the marine sponge Suberites domuncula through activation of bone morphogenetic protein-1
	Mueller, Werner E. G.5; Binder, Michael 5; von Lintig, Johannes 1; Guo, Yue-Wei2 ; Wang, Xiaohong 3,5; Kaandorp, Jaap A.4; Wiens, Matthias 5; Schroeder, Heinz C.5
刊名	BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
	2011-12
卷号	1810 期号:12 页码:1178-1194
关键词	Retinoic acid BMP-1 beta-Carotene dioxygenase Retinal dehydrogenase Silicatein Silintaphin-2
ISSN号	0304-4165
DOI	10.1016/j.bbagen.2011.09.006
文献子类	Article
英文摘要	Background: The formation of the spicules in siliceous sponges involves the formation of cylinder-like structures in the extraspicular space, composed of the enzyme silicatein and the calcium-dependent lectin. Scope of review: Molecular cloning of the cDNAs (carotene dioxygenase, retinal dehydrogenase, and BMB-1 [bone morphogenic protein-1]) from the demosponge Suberites domuncula was performed. These tools were used to understand the retinoid metabolism in the animal by gRT-PCR, immunoblotting and TEM. Major conclusions: We demonstrate that silintaphin-2, a silicatein-interacting protein, is processed from a longer-sized 15-kDa precursor to a truncated, shorter-sized 13 kDa calcium-binding protein via proteolytic cleavage at the dipeptide Ala down arrow Asp, mediated by BMP-1. The expression of this protease as well as the expression of two key enzymes of the carotinoid metabolism, the beta beta-carotene-15,15'-dioxygenase and the retinal dehydrogenase/reductase, were found to be strongly up-regulated by retinoic acid. Hence retinoic acid turned out to be a key factor in skeletogenesis in the most ancient still existing metazoans, the sponges. General significance: It is shown that retinoic acid regulates the formation of the organic cylinder that surrounds the axis of the spicules and enables, as a scaffold, the radial apposition of new silica layers and hence the growth of the spicules. (C) 2011 Elsevier B.V. All rights reserved.
资助项目	ERC[268476 - BIOSILICA] ; German Bundesministerium fur Bildung und Forschung[00000000] ; Deutsche Forschungsgemeinschaft[Schr 277/10-1] ; European Commission/EUREKA (EUROSTARS)[4289 - SILIBACTS] ; International Human Frontier Science Program[00000000] ; European Commission[244967 - Mem-S] ; Ministry of Land and Resources of the People's Republic of China[201011005-06] ; International S & T Cooperation Program of China[2008DFA00980]
WOS关键词	SHORT-CHAIN DEHYDROGENASE/REDUCTASE ; PROCOLLAGEN C-PROTEINASE ; MINIMAL DOMAIN-STRUCTURE ; GEODIA-CYDONIUM LECTIN ; VITAMIN-A PRODUCTION ; FRESH-WATER SPONGES ; BETA-CAROTENE ; IN-VITRO ; SILICEOUS SPICULES ; BINDING-PROTEINS
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000297885300007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278316]
专题	天然药物化学研究室
通讯作者	Mueller, Werner E. G.
作者单位	1.Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44160 USA; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Natl Res Ctr Geoanal, Beijing 100037, Peoples R China; 4.Univ Amsterdam, Sect Computat Sci, NL-1098 SJ Amsterdam, Netherlands 5.Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Physiol Chem, ERC Adv Grant Res Grp, D-55128 Mainz, Germany;
推荐引用方式 GB/T 7714	Mueller, Werner E. G.,Binder, Michael,von Lintig, Johannes,et al. Interaction of the retinoic acid signaling pathway with spicule formation in the marine sponge Suberites domuncula through activation of bone morphogenetic protein-1[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,2011,1810(12):1178-1194.
APA	Mueller, Werner E. G..,Binder, Michael.,von Lintig, Johannes.,Guo, Yue-Wei.,Wang, Xiaohong.,...&Schroeder, Heinz C..(2011).Interaction of the retinoic acid signaling pathway with spicule formation in the marine sponge Suberites domuncula through activation of bone morphogenetic protein-1.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1810(12),1178-1194.
MLA	Mueller, Werner E. G.,et al."Interaction of the retinoic acid signaling pathway with spicule formation in the marine sponge Suberites domuncula through activation of bone morphogenetic protein-1".BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1810.12(2011):1178-1194.