p38 MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION IN AMYGDALA MEDIATES kappa OPIOID RECEPTOR AGONIST U50,488H-INDUCED CONDITIONED PLACE AVERSION

doi:10.1016/j.neuroscience.2016.01.052

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	p38 MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION IN AMYGDALA MEDIATES kappa OPIOID RECEPTOR AGONIST U50,488H-INDUCED CONDITIONED PLACE AVERSION
	Zan, G. -Y.2,5; Wang, Q.3; Wang, Y. -J.2,5; Chen, J. -C.4; Wu, X.4; Yang, C. -H.4; Chai, J. -R.2,5; Li, M.2,5 ; Liu, Y.1; Hu, X. -W.4
刊名	NEUROSCIENCE
	2016-04-21
卷号	320 页码:122-128
关键词	kappa opioid receptor U50 488H conditioned place aversion p38 MAPK
ISSN号	0306-4522
DOI	10.1016/j.neuroscience.2016.01.052
文献子类	Article
英文摘要	kappa opioid receptor agonists produce aversive effects in rodents, however the underlying mechanisms remain unclear. Activation of p38 mitogen-activated protein kinase (MAPK) has been discovered to play a critical role in the modulation of affective behaviors. The present study was undertaken to detect the possible involvement of p38 MAPK in the aversive effects induced by kappa opioid receptor activation. We found that the kappa opioid receptor agonist trans-(+/-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl] benzenacetamide methanesulfonate salt (U50,488H) produced significant place aversion in mice as measured by the conditioned place preference procedure, accompanied with significant p38 MAPK activation in the amygdala, but not in the nucleus accumbens and hippocampus. Stereotaxic microinjection of the p38 MAPK inhibitor 4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridy-l)-1H-imidazole (SB203580) into amygdala significantly inhibited p38 MAPK activation and completely blocked the conditioned place aversion in mice. Thus, these results suggested that activation of p38 MAPK in the amygdala was required to mediate kappa opioid receptor-induced aversive behavior. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
资助项目	Ministry of Science and Technology of China[2013CB835100] ; Ministry of Science and Technology of China[2015CB553500] ; National Natural Science Foundation of China[81171296] ; National Natural Science Foundation of China[81130087] ; National Natural Science Foundation of China[91232716] ; Committee of Science and Technology of Shanghai[13JC140680]
WOS关键词	OPIATE RECEPTORS ; MAPK ACTIVATION ; STRESS ; PREFERENCE ; SYSTEM ; RATS ; ADDICTION ; NEURONS ; ANXIETY ; TRAFFICKING
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000371834500011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276070]
专题	药理学第二研究室
通讯作者	Hu, X. -W.; Shu, X. -H.; Liu, J. -G.
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China 2.Collaborat Innovat Ctr Brain Sci, Shanghai 201203, Peoples R China; 3.Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China; 4.Changhai Hosp, Dept Neurosurg, Shanghai 200433, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zan, G. -Y.,Wang, Q.,Wang, Y. -J.,et al. p38 MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION IN AMYGDALA MEDIATES kappa OPIOID RECEPTOR AGONIST U50,488H-INDUCED CONDITIONED PLACE AVERSION[J]. NEUROSCIENCE,2016,320:122-128.
APA	Zan, G. -Y..,Wang, Q..,Wang, Y. -J..,Chen, J. -C..,Wu, X..,...&Liu, J. -G..(2016).p38 MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION IN AMYGDALA MEDIATES kappa OPIOID RECEPTOR AGONIST U50,488H-INDUCED CONDITIONED PLACE AVERSION.NEUROSCIENCE,320,122-128.
MLA	Zan, G. -Y.,et al."p38 MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION IN AMYGDALA MEDIATES kappa OPIOID RECEPTOR AGONIST U50,488H-INDUCED CONDITIONED PLACE AVERSION".NEUROSCIENCE 320(2016):122-128.