Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease

doi:10.1038/ncomms13419

	Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease
	Mottawea, Walid 2,3,4; Chiang, Cheng-Kang 2,3; Muelbauer, Marcus 5; Starr, Amanda E.2,3; Butcher, James 2,3; Abujamel, Turki 2,3; Deeke, Shelley A.2,3; Brandel, Annette 2,3; Zhou, Hu3,6 ; Shokralla, Shadi 7
刊名	NATURE COMMUNICATIONS
	2016-11-23
卷号	7
ISSN号	2041-1723
DOI	10.1038/ncomms13419
文献子类	Article
英文摘要	Intestinal microbial dysbiosis is associated with Crohn's disease (CD). However, the mechanisms leading to the chronic mucosal inflammation that characterizes this disease remain unclear. In this report, we use systems-level approaches to study the interactions between the gut microbiota and host in new-onset paediatric patients to evaluate causality and mechanisms of disease. We report an altered host proteome in CD patients indicative of impaired mitochondrial functions. In particular, mitochondrial proteins implicated in H2S detoxification are downregulated, while the relative abundance of H2S microbial producers is increased. Network correlation analysis reveals that Atopobium parvulum controls the central hub of H2S producers. A. parvulum induces pancolitis in colitis-susceptible interleukin-10-deficient mice and this phenotype requires the presence of the intestinal microbiota. Administrating the H2S scavenger bismuth mitigates A. parvulum-induced colitis in vivo. This study reveals that host-microbiota interactions are disturbed in CD and thus provides mechanistic insights into CD pathogenesis.
资助项目	Government of Canada through Genome Canada[00000000] ; Ontario Genomics Institute[OGI-067] ; CIHR[GPH-129340] ; CIHR[MOP-114872] ; CIHR[117960-1] ; Ontario Ministry of Economic Development and Innovation[REG1-4450] ; IBD foundation[00000000] ; Crohn's and Colitis Canada (CCC)[00000000] ; CHEO foundation[00000000] ; Children's Hospital of Eastern Ontario Research Institute[00000000] ; Faculty of Medicine of the University of Ottawa[00000000] ; NIH[R01 DK73338] ; NIH[R01 DK47700] ; NIH[R21 CA195226] ; CGIBD[P30 DK034987] ; Mansoura University, Egypt[00000000] ; King Abdulaziz University through the Saudi Arabian Cultural Bureau in Canada[00000000] ; CCFA[00000000] ; Canadian Child Health Clinician Scientist Program[00000000] ; Canadian Institutes of Health Research[00000000] ; Canadian Association of Gastroenterology[00000000] ; Crohn's and Colitis Canada[00000000] ; CIHR/CAG/CCC Postdoctoral Award[00000000]
WOS关键词	INFLAMMATORY-BOWEL-DISEASE ; COA-TRANSFERASE GENES ; ULCERATIVE-COLITIS ; CAMPYLOBACTER-JEJUNI ; HYDROGEN-SULFIDE ; PROSPECTIVE MULTICENTER ; BARRIER DYSFUNCTION ; NONINFLAMED ILEUM ; ENTERAL NUTRITION ; INTERACTIVE TREE
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000388319900001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275800]
专题	分析化学研究室
通讯作者	Jobin, Christian; Mack, David R.; Stintzi, Alain
作者单位	1.Univ Ottawa, Sch Epidemiol Publ Hlth & Prevent Med, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada; 2.Univ Ottawa, Dept Biochem Microbiol & Immunol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada; 3.Univ Ottawa, Ottawa Inst Syst Biol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada; 4.Mansoura Univ, Fac Pharm, Dept Microbiol & Immunol, Mansoura 35516, Egypt; 5.Univ Florida, Dept Med, Div Gastroenterol Hepatol & Nutr, Gainesville, FL 32611 USA; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 7.Univ Guelph, Biodivers Inst Ontario, Dept Integrat Biol, Guelph, ON N1G 2W1, Canada; 8.Childrens Hosp Eastern Ontario, Ctr Inflammatory Bowel Dis, 451 Smyth Rd, Ottawa, ON K1H 8L1, Canada; 9.CHEO, Res Inst, 451 Smyth Rd, Ottawa, ON K1H 8L1, Canada; 10.Univ Ottawa, Dept Pediat, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada;
推荐引用方式 GB/T 7714	Mottawea, Walid,Chiang, Cheng-Kang,Muelbauer, Marcus,et al. Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease[J]. NATURE COMMUNICATIONS,2016,7.
APA	Mottawea, Walid.,Chiang, Cheng-Kang.,Muelbauer, Marcus.,Starr, Amanda E..,Butcher, James.,...&Stintzi, Alain.(2016).Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease.NATURE COMMUNICATIONS,7.
MLA	Mottawea, Walid,et al."Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease".NATURE COMMUNICATIONS 7(2016).