Basic fibroblast growth factor protected forebrain against ischemia-reperfusion damage in rats

	Basic fibroblast growth factor protected forebrain against ischemia-reperfusion damage in rats
	Liu, X; Zhu, XZ
刊名	ACTA PHARMACOLOGICA SINICA
	1998-11
卷号	19 期号:6 页码:527-530
关键词	basic fibroblast growth factor reperfusion injury visual cortex dopamine water sodium potassium high pressure liquid chromatography corpus striatum
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To study the effect of basic fibroblast growth factor (bFGF) on acute forebrain ischemia-reperfusion injury in rats. METHODS: Both vertebral arteries were occluded by electrocautery and severe but transient bilateral cerebral ischemia was produced by clamping both common carotid arteries for 20 min in rats. The contents of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in striatum were determined by HPLC with electrochemic detector (HPLC-EC) at 3, 6, 12, 24 h after the onset of reperfusion. The contents of sodium, potassium in forebrain were determined by atomic absorption spectro-photometric method at 6-h reperfusion. Morphological changes of the striatum were also examined. RESULTS: At 6-h reperfusion, the DA content in striatum decreased from (99 +/- 16) mu g . g(-1)(protein) in sham-operation group to (70 +/- 20) mu g . g(-1) (protein); the water and the sodium contents in forebrain increased from 77.34% +/- 0.19% to 79.6% +/- 0.6% and from (9.3 +/- 0.6) to (10.5 +/- 0.6) mg . g(-1) (dry weight), respectively, bFGF (iv 45 mu g . kg(-1) . h(-1) for 3 h) from the start of reperfusion prevented the decrease of DA in striatum and the increases of water and sodium contents in forebrain. Histological examination also indicated that bFGF ameliorated the injury of neurons. CONCLUSION: bFGF prevented the brain from injury of ischemia and reperfusion.
WOS关键词	FOCAL CEREBRAL-ISCHEMIA ; HIPPOCAMPAL-NEURONS ; NITRIC-OXIDE ; GLUTAMATE ; DOPAMINE
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000076914200007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274793]
专题	分析化学研究室药理学第二研究室药物安全性评价中心
通讯作者	Zhu, XZ
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Liu, X,Zhu, XZ. Basic fibroblast growth factor protected forebrain against ischemia-reperfusion damage in rats[J]. ACTA PHARMACOLOGICA SINICA,1998,19(6):527-530.
APA	Liu, X,&Zhu, XZ.(1998).Basic fibroblast growth factor protected forebrain against ischemia-reperfusion damage in rats.ACTA PHARMACOLOGICA SINICA,19(6),527-530.
MLA	Liu, X,et al."Basic fibroblast growth factor protected forebrain against ischemia-reperfusion damage in rats".ACTA PHARMACOLOGICA SINICA 19.6(1998):527-530.