Alkyl phloroglucinol derivatives from Syzygium levinei and their differentiation-inducing activity

doi:10.1055/s-2006-931559

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Alkyl phloroglucinol derivatives from Syzygium levinei and their differentiation-inducing activity
	Zou, J ; Mi, Y ; Chen, WL ; Liu, QF; Wang, J ; Lou, LG; Zhao, WM
刊名	PLANTA MEDICA
	2006-05
卷号	72 期号:6 页码:533-538
关键词	Syzygium levinei Myrtaceae alkyl phloroglucinol cell growth inhibition differentiation-inducing factor
ISSN号	0032-0943
DOI	10.1055/s-2006-931559
文献子类	Article
英文摘要	Eleven compounds have been identified from the whole plants of Syzygium levinei (Myrtaceae) on the basis of spectroscopic analysis and chemical methods. Among these compounds, (Z)-1-(2,6-dihy roxy-4-methoxyphenyl)-oct-5-en-1-one (1), (3E,7Z)-1-(2,6-dihydroxy-4-methoxyphenyl)-deca-3,7-dien-1 -one (2), and 1-(2-0-0-D-glucopyranosyl-5,6-dihydroxy-4-methoxyphenyl)-octan-1 -one (3) were characterized as new alkyl phloroglucinol derivatives, and 1-(2,6-dihydroxy-4- methoxyphenyl)- hexan-1-one (4) was identified as a new natural product. Compounds 1, 2, and 4 were found to inhibit the proliferation of leukemia K562 and HL-60 cells and also to induce the differentiation of K562 cells as determined by the appearance of matured morphology and the increase in the intracellular hemoglobin level.
WOS关键词	DICTYOSTELIUM-DISCOIDEUM ; TRITERPENOIDS ; GLUCOSIDE ; LEUKEMIA ; AROMATICUM ; GLYCOSIDES ; TANNINS ; CELLS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000238018100010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273614]
专题	药理学第一研究室天然药物化学研究室
通讯作者	Lou, LG
作者单位	1.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zou, J,Mi, Y,Chen, WL,et al. Alkyl phloroglucinol derivatives from Syzygium levinei and their differentiation-inducing activity[J]. PLANTA MEDICA,2006,72(6):533-538.
APA	Zou, J.,Mi, Y.,Chen, WL.,Liu, QF.,Wang, J.,...&Zhao, WM.(2006).Alkyl phloroglucinol derivatives from Syzygium levinei and their differentiation-inducing activity.PLANTA MEDICA,72(6),533-538.
MLA	Zou, J,et al."Alkyl phloroglucinol derivatives from Syzygium levinei and their differentiation-inducing activity".PLANTA MEDICA 72.6(2006):533-538.