Annotinolide F and lycoannotines A-I, further Lycopodium alkaloids from Lycopodium annotinum

doi:10.1016/j.phytochem.2017.07.003

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	Annotinolide F and lycoannotines A-I, further Lycopodium alkaloids from Lycopodium annotinum
	Tang, Yu 1; Xiong, Juan 1; Zou, Yike 2; Wang, Wei 3; Huang, Chao 1; Zhang, Hai-Yan3 ; Hu, Jin-Feng 1
刊名	PHYTOCHEMISTRY
	2017-11
卷号	143 页码:1-11
关键词	Lycopodium annotinum Lycopodiaceae Lycopodium alkaloids Annotinolide F Lycoannotines
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2017.07.003
文献子类	Article
英文摘要	Seven lycopodine-type (annotinolide F and lycoannotines A-F), two lycodine-type (lycoannotines G and H), and one fawcettimine-type (lycoannotine I) previously undescribed naturally occurring Lycopodium alkaloids together with thirteen known ones were isolated from the whole plant of Lycopodium annotinum. Their structures and absolute configurations were determined by extensive spectroscopic methods, single-crystal X-ray diffraction, chemical transformation, and electronic circular dichroism (ECD) calculations. Among the isolates, annotinolide F, lycoannotines A and B are unusual 7,8-secolycopodane derivatives, and annotinolide F even further possesses a rare 8,5-lactone framework through a lactonization after the C-7/C-8 bond cleavage. Lycoannotine C is an uncommon 8,15-seco lycopodine-type alkaloid, whereas lycoannotine I represents the first example of a naturally occurring C-9/N bond cleavage product of fawcettimine-type alkaloid. Among them, only lycoannotine I was found to show considerable anti-butyrylcholinesterase (anti-BuChE) activity. (C) 2017 Elsevier Ltd. All rights reserved.
资助项目	NSFC[21472021] ; National Basic Research Program of China (973 Program)[2013CB530700]
WOS关键词	ALZHEIMERS-DISEASE ; ACETYLCHOLINESTERASE ; HUPERZINE
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000413128900001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272435]
专题	药理学第二研究室
通讯作者	Hu, Jin-Feng
作者单位	1.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; 2.Univ Penn, Dept Chem, 231 S 34 St, Philadelphia, PA 19104 USA; 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Tang, Yu,Xiong, Juan,Zou, Yike,et al. Annotinolide F and lycoannotines A-I, further Lycopodium alkaloids from Lycopodium annotinum[J]. PHYTOCHEMISTRY,2017,143:1-11.
APA	Tang, Yu.,Xiong, Juan.,Zou, Yike.,Wang, Wei.,Huang, Chao.,...&Hu, Jin-Feng.(2017).Annotinolide F and lycoannotines A-I, further Lycopodium alkaloids from Lycopodium annotinum.PHYTOCHEMISTRY,143,1-11.
MLA	Tang, Yu,et al."Annotinolide F and lycoannotines A-I, further Lycopodium alkaloids from Lycopodium annotinum".PHYTOCHEMISTRY 143(2017):1-11.