化学生物学导向的HIV-1整合酶抑制剂的发现和结构优化

	化学生物学导向的HIV-1整合酶抑制剂的发现和结构优化
	龙亚秋; 曾立凡; 李慧媛; 姜晓华; 黄少胥
	2006-07-01
关键词	HIV-1整合酶抑制剂杂合体先导化合物结构优化
页码	1
英文摘要	HIV-1 integrase (IN) is an essential enzyme for the viral replication and has no mammalian counterpart, thus IN becomes an attractive target for antiviral drug design. However, the lack of detailed structural information about the interaction between IN and its substrate or inhibitors prevents the discovery and development of bona fide HIV-1 IN inhibitors into clinical use. By the means of chemical biology, we explore and build the binding mode of IN with inhibitors, then design and discover new structure HIV-1 integrase inhibitors. Furthermore, we propose and try a new concept of hybride HIV-1 integrase inhibitors which target the different stages of the integration, providing promising new lead compounds for the development of anti-HIV agents.
会议录	中国化学会第二十五届学术年会论文摘要集（上册）
文献子类	Article
语种	中文
内容类型	会议论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267557]
专题	药物化学研究室
推荐引用方式 GB/T 7714	龙亚秋,曾立凡,李慧媛,等. 化学生物学导向的HIV-1整合酶抑制剂的发现和结构优化[C]. 见:.