Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis

doi:10.1016/j.bmcl.2018.12.004

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室 > 郭跃伟课题组

	Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis
	Wu, Qihao 1,3; Li, Xu-Wen1 ; Li, Heng 1; Yao, Li-Gong 1; Tang, Wei1 ; Miao, Ze-Hong 1; Wang, Hong 2; Guo, Yue-Wei1,2
刊名	Bioorganic & medicinal chemistry letters
	2019-01-15
卷号	29 期号:2 页码:185-188
ISSN号	1464-3405
DOI	10.1016/j.bmcl.2018.12.004
文献子类	Article
英文摘要	Different chemotypes of Sinularia flexibilis exist in the Hainan island. Thus, a collection of this soft coral from a location different from the one of our previous study afforded three novel cembranoid esters featuring a n-butyl alcohol moiety, a structural element rare in natural products of both terrestrial and marine origin. The structures of the new compounds were elucidated by detailed spectroscopic analysis and by the comparison of their spectroscopic data with those reported in the literature. In addition, the absolute stereochemistry of the previously reported diepoxycembrene (9) was first time determined by the X-ray diffraction analysis. In bioassays, compounds 6-8 exhibited strong anti-inflammatory effect with IC values of 2.7, 4.7, and 4.2 μM, respectively, whereas compound 5 displayed cytotoxicity against several cancer cells with IC values ranging from 8.9 to 27.4 μM. A preliminary structural-activity relationship (SAR) was also described.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266360]
专题	天然药物化学研究室_郭跃伟课题组
通讯作者	Wang, Hong; Guo, Yue-Wei
作者单位	1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; 2.College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China 3.College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China;
推荐引用方式 GB/T 7714	Wu, Qihao,Li, Xu-Wen,Li, Heng,et al. Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis[J]. Bioorganic & medicinal chemistry letters,2019,29(2):185-188.
APA	Wu, Qihao.,Li, Xu-Wen.,Li, Heng.,Yao, Li-Gong.,Tang, Wei.,...&Guo, Yue-Wei.(2019).Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis.Bioorganic & medicinal chemistry letters,29(2),185-188.
MLA	Wu, Qihao,et al."Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis".Bioorganic & medicinal chemistry letters 29.2(2019):185-188.