Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals

doi:10.1039/c8ce00689j

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物质量控制与固体化学研究中心

	Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals
	Wang, Feng-Yuan 1,2; Zhang, Qi 2; Zhang, Zaiyong 2; Gong, Xiaoyi 2; Wang, Jian-Rong2 ; Mei, Xuefeng2
刊名	CRYSTENGCOMM
	2018-10-21
卷号	20 期号:39 页码:5945-5948
ISSN号	1466-8033
DOI	10.1039/c8ce00689j
文献子类	Article
英文摘要	Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral agent, with nicotinamide, caffeine, and acetylsalicylic acid were successfully designed and synthesized. Both the apparent solubility and intrinsic dissolution rate of apremilast in a pH 2.0 buffer have been improved via the formation of cocrystals.
资助项目	Shanghai Natural Science Foundation[18ZR1447900] ; Youth Innovation Promotion Association CAS[2016257] ; CAS Key Technology Talent Program[00000000] ; SANOFI-SIBS Scholarship[00000000]
WOS关键词	PHARMACEUTICAL COCRYSTALS ; CO-CRYSTALS
WOS研究方向	Chemistry ; Crystallography
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000448408200008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279529]
专题	药物质量控制与固体化学研究中心
通讯作者	Mei, Xuefeng
作者单位	1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Feng-Yuan,Zhang, Qi,Zhang, Zaiyong,et al. Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals[J]. CRYSTENGCOMM,2018,20(39):5945-5948.
APA	Wang, Feng-Yuan,Zhang, Qi,Zhang, Zaiyong,Gong, Xiaoyi,Wang, Jian-Rong,&Mei, Xuefeng.(2018).Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals.CRYSTENGCOMM,20(39),5945-5948.
MLA	Wang, Feng-Yuan,et al."Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals".CRYSTENGCOMM 20.39(2018):5945-5948.