New Polymorphs of Huperzine A: Preparation, Structures, and Physicochemical Properties of Anhydrous Crystal Forms

doi:10.1021/cg400313a

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	New Polymorphs of Huperzine A: Preparation, Structures, and Physicochemical Properties of Anhydrous Crystal Forms
	Zhang, Qi; Lu, Liye; Dai, Wenjuan; Mei, Xuefeng
刊名	CRYSTAL GROWTH & DESIGN
	2013-05
卷号	13 期号:5 页码:2198-2207
ISSN号	1528-7483
DOI	10.1021/cg400313a
文献子类	Article
英文摘要	Three new polymorphs (forms I, II, and III) of natural cholinesterase inhibitor Huperzine A were discovered through a comprehensive polymorph screening experiment. Their structures were elucidated by single crystal structure analysis and characterized by powder X-ray diffraction, Fourier transform-infrared spectroscopy, and DXR Raman microscope. The physicochemical properties of these new forms were investigated by thermal analysis (TGA and DSC) and dynamic vapor sorption (DVS) isotherms. The powder dissolution rates were compared with the marketed monohydrate form. Thermodynamic stability, phase transformation, E-T diagram, and drugability properties are also discussed in detail.
资助项目	National Natural Science Foundation of China[81273479] ; Chinese Academy of Science[00000000]
WOS关键词	PHARMACEUTICAL SOLID POLYMORPHISM ; SELECTIVE CRYSTALLIZATION ; ALZHEIMERS-DISEASE ; DRUG APPLICATIONS ; TABLETS ; SPECTROSCOPY ; INSIGHTS ; SYSTEM
WOS研究方向	Chemistry ; Crystallography ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000318468400049
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277636]
专题	药物质量控制与固体化学研究中心药物安全性评价中心
通讯作者	Mei, Xuefeng
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Qi,Lu, Liye,Dai, Wenjuan,et al. New Polymorphs of Huperzine A: Preparation, Structures, and Physicochemical Properties of Anhydrous Crystal Forms[J]. CRYSTAL GROWTH & DESIGN,2013,13(5):2198-2207.
APA	Zhang, Qi,Lu, Liye,Dai, Wenjuan,&Mei, Xuefeng.(2013).New Polymorphs of Huperzine A: Preparation, Structures, and Physicochemical Properties of Anhydrous Crystal Forms.CRYSTAL GROWTH & DESIGN,13(5),2198-2207.
MLA	Zhang, Qi,et al."New Polymorphs of Huperzine A: Preparation, Structures, and Physicochemical Properties of Anhydrous Crystal Forms".CRYSTAL GROWTH & DESIGN 13.5(2013):2198-2207.