Polymorphism and isomorphism of Huperzine A solvates: structure, properties and form transformation

doi:10.1039/c3ce41965g

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物质量控制与固体化学研究中心

	Polymorphism and isomorphism of Huperzine A solvates: structure, properties and form transformation
	Zhang, Qi; Lu, Liye; Dai, Wenjuan; Mei, Xuefeng
刊名	CRYSTENGCOMM
	2014
卷号	16 期号:10 页码:1919-1926
ISSN号	1466-8033
DOI	10.1039/c3ce41965g
文献子类	Article
英文摘要	Huperzine A is a naturally occurring alkaloid used in clinical treatments for Alzheimer disease. The drug has also been widely used in dietary supplements for improving memory loss and mental impairment. There are three polymorphs and a monohydrate form reported in the literature. In present work, single crystal structures of a new polymorphic monohydrate and four organic solvates were described. The study of single crystal structures of solvates was used as an example to illustrate the formation of different, yet reoccurring packing patterns depending on the inclusion solvent structures. The physicochemical properties of each solvate were examined by a variety of analytical techniques, including PXRD, Raman, IR, DSC, TGA and DVS etc. Form transformation between solvates and hydrates and desolvation processes were studied by DVS isotherms and slurry experiments. The packing efficiency of various solid-state forms, including three pure polymorphs and six solvates crystals were also compared and the results were correlated with their thermo stabilities.
WOS关键词	SOLID-STATE FORMS ; CRYSTAL-STRUCTURES ; PHYSICOCHEMICAL PROPERTIES ; DESOLVATION KINETICS ; DEHYDRATION KINETICS ; MEDICINAL COMPOUNDS ; SIZE-REDUCTION ; HYDROCHLORIDE ; MONOHYDRATE ; SULFATHIAZOLE
WOS研究方向	Chemistry ; Crystallography
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000331176000009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277309]
专题	药物质量控制与固体化学研究中心药物安全性评价中心
通讯作者	Zhang, Qi
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Qi,Lu, Liye,Dai, Wenjuan,et al. Polymorphism and isomorphism of Huperzine A solvates: structure, properties and form transformation[J]. CRYSTENGCOMM,2014,16(10):1919-1926.
APA	Zhang, Qi,Lu, Liye,Dai, Wenjuan,&Mei, Xuefeng.(2014).Polymorphism and isomorphism of Huperzine A solvates: structure, properties and form transformation.CRYSTENGCOMM,16(10),1919-1926.
MLA	Zhang, Qi,et al."Polymorphism and isomorphism of Huperzine A solvates: structure, properties and form transformation".CRYSTENGCOMM 16.10(2014):1919-1926.