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	Eutypenoids A-C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1
	Zhang, Liu-Qiang2; Chen, Xiao-Chong2; Chen, Zhao-Qiang3; Wang, Gui-Min3; Zhu, Shi-Guo2; Yang, Yi-Fu2; Chen, Kai-Xian2,3; Liu, Xiao-Yu1; Li, Yi-Ming2
刊名	MARINE DRUGS
	2016-03
卷号	14期号:3
关键词	eutypenoid Arctic fungi Eutypella novel pimarane diterpenes immunosuppressive effect
ISSN号	1660-3397
DOI	10.3390/md14030044
文献子类	Article
英文摘要	Eutypenoids A-C (1-3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass spectroscopy (MS), nuclear magnetic resonance (NMR), X-ray crystallography, and electronic circular dichroism (ECD) analysis. The immunosuppressive effects of eutypenoids A-C (1-3) were studied using a ConA-induced splenocyte proliferation model, which suggested that 2 exhibited potent immunosuppressive activities.
资助项目	National High Technology Research and Development Program of China (863 program)[2013AA093003] ; Program for Professors of Special Appointment (Eastern Scholar) in the Shanghai Institutions of Higher Learning[2012-90] ; National Natural Science Foundation of China[81173518] ; National Natural Science Foundation of China[81261120567]
WOS关键词	MARINE NATURAL-PRODUCTS ; ELECTRONIC CIRCULAR-DICHROISM ; SCOPARIA FS26 ; CYTOCHALASINS ; MACROPHAGES
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	MDPI AG
WOS记录号	WOS:000373701200015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276113]
专题	药物发现与设计中心
通讯作者	Liu, Xiao-Yu; Li, Yi-Ming
作者单位	1.Second Mil Med Univ, Dept Biochem & Mol Biol, 800 Xiangyin Rd, Shanghai 200433, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, Liu-Qiang,Chen, Xiao-Chong,Chen, Zhao-Qiang,et al. Eutypenoids A-C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1[J]. MARINE DRUGS,2016,14(3).
APA	Zhang, Liu-Qiang.,Chen, Xiao-Chong.,Chen, Zhao-Qiang.,Wang, Gui-Min.,Zhu, Shi-Guo.,...&Li, Yi-Ming.(2016).Eutypenoids A-C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1.MARINE DRUGS,14(3).
MLA	Zhang, Liu-Qiang,et al."Eutypenoids A-C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1".MARINE DRUGS 14.3(2016).

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