Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells

doi:10.1038/srep37417

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	Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells
	Kong, Yuanyuan 2; Chen, Gege 2; Xu, Zhijian3 ; Yang, Guang 2; Li, Bo 3; Wu, Xiaosong 2; Xiao, Wenqin 2; Xie, Bingqian 2; Hu, Liangning 2; Sun, Xi 2
刊名	SCIENTIFIC REPORTS
	2016-11-21
卷号	6
ISSN号	2045-2322
DOI	10.1038/srep37417
文献子类	Article
英文摘要	Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Pterostilbene, a natural dimethylated analog of resveratrol, has been shown to possess diverse pharmacological activities, including anti-inflammatory, antioxidant and anticancer properties. However, to the best of our knowledge, there has been no study of the effects of pterostilbene upon hematological malignancies. Herein, we report the antitumor activity and mechanism of pterostilbene against DLBCL cells both in vitro and in vivo. We found that pterostilbene treatment resulted in a dose-dependent inhibition of cell viability. In addition, pterostilbene exhibited a strong cytotoxic effect, as evidenced not only by reductions of mitochondrial membrane potential (MMP) but also by increases in cellular apoptotic index and reactive oxygen species (ROS) levels, leading to arrest in the S-phase of the cell cycle. Furthermore, pterostilbene treatment directly up-regulated p-p38MAPK and downregulated p-ERK1/2. In vivo, intravenous administration of pterostilbene inhibited tumor development in xenograft mouse models. Overall, the results suggested that pterostilbene is a potential anti-cancer pharmaceutical against human DLBCL by a mechanism involving the suppression of ERK1/2 and activation of p38MAPK signaling pathways.
资助项目	National Natural Science Foundation of China[81372391] ; National Natural Science Foundation of China[31271496] ; National Natural Science Foundation of China[81300443] ; National Natural Science Foundation of China[81570190] ; National Natural Science Foundation of China[81529001] ; National Natural Science Foundation of China[81302699]
WOS关键词	COLON-CANCER CELLS ; LEUKEMIA-CELLS ; CARCINOMA CELLS ; RESVERATROL ; EXPRESSION ; GENE ; BLUEBERRIES ; CARCINOGENESIS ; CONSTITUENT ; ANTICANCER
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000388196200001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275802]
专题	药物发现与设计中心
通讯作者	Tao, Yi; Zhu, Weiliang; Shi, Jumei
作者单位	1.Tongji Univ, Coll Life Sci & Technol, Shanghai 200092, Peoples R China 2.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Hematol, Shanghai 200072, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Kong, Yuanyuan,Chen, Gege,Xu, Zhijian,et al. Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells[J]. SCIENTIFIC REPORTS,2016,6.
APA	Kong, Yuanyuan.,Chen, Gege.,Xu, Zhijian.,Yang, Guang.,Li, Bo.,...&Shi, Jumei.(2016).Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells.SCIENTIFIC REPORTS,6.
MLA	Kong, Yuanyuan,et al."Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells".SCIENTIFIC REPORTS 6(2016).