Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta

	Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta
	Du Jing 1; Ding Jie 1; Mu Zhen-Qiang 1; Guan Shu-Hong3 ; Cheng Chun-Ru 1; Liu Xuan 2; Guo De-An3
刊名	CHINESE JOURNAL OF NATURAL MEDICINES
	2018-02
卷号	16 期号:2 页码:139-142
关键词	Pinellia pedatisecta Alkaloids Structure identification Anti-tumor
ISSN号	2095-6975
文献子类	Article
英文摘要	The present study was designed to determine the chemical constituents of the stem tuber of Pinellia pedatisecta. The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Three new alkaloids (compounds 1, 2, and 3) were obtained and identified as 9-((5-methoxypyridin-2-yl) methyl)-9H-purin-6-amine (1),4-(2-(2, 5-dioxopyrrolidin-1-yl) ethyl) phenyl acetate (2), and N-(9-((5-methoxypyridin-2-yl) methyl)-9H-purin-6-yl) acetamide (3). These compounds were evaluated for their cytotoxicity against human cervical cancer HeLa cells. Compounds 1 and 3 significantly inhibited the proliferation of HeLa cells with IC50 values being 3.02 +/- 0.54 and 7.16 +/- 0.62 mu mol.L-1, respectively.
资助项目	National Natural Science Foundation of China[81373964] ; Introduction Program of Scientific Researcher of Sichuan University of Science Engineering[2016RCL07] ; Introduction Program of Scientific Researcher of Sichuan University of Science Engineering[2017RCL61] ; Opening Project of Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education[LYJ1302] ; Scientific Research Fund of the Sichuan Provincial Education Department[13ZB0133] ; Science and Technology Program Project of Sichuan[2015JY0024]
WOS研究方向	Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:6171808
出版者	CHINESE JOURNAL NATURAL MEDICINES
WOS记录号	WOS:000425298400008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279926]
专题	成果转移转化处上海中药现代化研究中心
通讯作者	Cheng Chun-Ru; Liu Xuan
作者单位	1.Sichuan Univ Sci & Engn, Sch Chem Engn, Sichuan Inst Higher Educ, Inst Pharmaceut Engn Technol & Applicat,Key Lab G, Zigong 643000, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Biomed Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Du Jing,Ding Jie,Mu Zhen-Qiang,et al. Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2018,16(2):139-142.
APA	Du Jing.,Ding Jie.,Mu Zhen-Qiang.,Guan Shu-Hong.,Cheng Chun-Ru.,...&Guo De-An.(2018).Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta.CHINESE JOURNAL OF NATURAL MEDICINES,16(2),139-142.
MLA	Du Jing,et al."Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta".CHINESE JOURNAL OF NATURAL MEDICINES 16.2(2018):139-142.