7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities

doi:10.1016/j.fitote.2018.01.007

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities
	Zheng, Yuan-Dong 1,2,3,4; Bai, Gang 1,2,4; Tang, Chunping2,3 ; Ke, Chang-Qiang2,3 ; Yao, Sheng2,3 ; Tong, Lin-Jiang 2,4; Feng, Fang 2,4; Li, Yan 2,4; Ding, Jian1,2,4 ; Xie, Hua2,4
刊名	FITOTERAPIA
	2018-03
卷号	125 页码:174-183
关键词	Podocarpus nagi Type B nagilactone Cytotoxic activity Apoptosis
ISSN号	0367-326X
DOI	10.1016/j.fitote.2018.01.007
文献子类	Article
英文摘要	A phytochemical investigation of twigs of Podocarpus nagi resulted in the identification of eight new type B nagilactones (1-8), all bearing a 7 alpha,8 alpha-epoxy-9(11)-enolide substructure, along with two known analogs (9-10). Their structures were determined on the basis of spectroscopic analysis, including HRESIMS, IR and NMR experiments, and X-ray crystallographic analysis. In vitro cytotoxic assay exhibited that compounds 1, 2, 9 and 10 could induce antiproliferation against three different types of human cancer cells while compounds 3 and 5 were inactive. Notably, the IC50 value of compound 1 is 0.208 mu M for A431 human epidermoid carcinoma cells, reaching the same level as the positive control combretastatin A-4 (0.104 mu M). Furthermore, compound 1 performed a strong inhibition of cancer cells by triggering apoptosis and arresting the cell cycle at G(1) phase. These results unfold potential anticancer therapeutic applications of type B nagilactones.
资助项目	Institutes for drug discovery and development[CASIMM0120164010] ; Strategic Pilot Projects[XDA12040318] ; Chinese Academy of Sciences[GJHZ1678] ; Chinese Academy of Sciences[GJHZ1739]
WOS关键词	NATURAL-PRODUCTS ; NORDITERPENE DILACTONES ; ANTICANCER DRUGS ; DISCOVERY ; MICROTUBULES ; NAGILACTONES ; PODOLACTONES ; PACLITAXEL ; LACTONES ; GROWTH
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000425560500027
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279881]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室天然药物化学研究室
通讯作者	Xie, Hua; Ye, Yang
作者单位	1.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
推荐引用方式 GB/T 7714	Zheng, Yuan-Dong,Bai, Gang,Tang, Chunping,et al. 7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities[J]. FITOTERAPIA,2018,125:174-183.
APA	Zheng, Yuan-Dong.,Bai, Gang.,Tang, Chunping.,Ke, Chang-Qiang.,Yao, Sheng.,...&Ye, Yang.(2018).7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities.FITOTERAPIA,125,174-183.
MLA	Zheng, Yuan-Dong,et al."7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities".FITOTERAPIA 125(2018):174-183.