Sarinfacetamides A and B, Nitrogenous Diterpenoids with Tricyclo[6.3.1.0(1,5)]dodecane Scaffold from the South China Sea Soft Coral Sarcophyton infundibuliforme

doi:10.1021/acs.orglett.8b00842

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	Sarinfacetamides A and B, Nitrogenous Diterpenoids with Tricyclo[6.3.1.0(1,5)]dodecane Scaffold from the South China Sea Soft Coral Sarcophyton infundibuliforme
	Ye, Fei 1,2; Li, Jing3 ; Wu, Yu 3; Zhu, Zheng-Dan 1,2; Mollo, Ernesto 5; Gavagnin, Margherita 5; Gu, Yu-Cheng 4; Zhu, Wei-Liang1,2,6 ; Li, Xu-Wen1,6 ; Guo, Yue-Wei1,2,6
刊名	ORGANIC LETTERS
	2018-05-04
卷号	20 期号:9 页码:2637-2640
ISSN号	1523-7060
DOI	10.1021/acs.orglett.8b00842
文献子类	Article
英文摘要	Two novel nitrogenous diterpenoids, sarinfacetamides A (1) and B (2), featuring an uncommon tricydo[6.3.1.0(1,5)]dodecane scaffold, and a known related diterpene (3) were isolated from the South China Sea soft coral Sarcophyton infundibuliforme. Their structures, including the absolute configuration of 1, were established, by extensive spectroscopic analysis and TDDFT-ECD calculation. Compounds 1 and 3 exhibited interesting promotion effects on the ConA-induced T lymphocyte proliferation. A plausible biosynthetic pathway for 1 and 2 was also proposed.
资助项目	National Natural Science Foundation of China (NSFC)[81520108028] ; National Natural Science Foundation of China (NSFC)[21672230] ; National Natural Science Foundation of China (NSFC)[81603022] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; SKLDR/SIMM Project[SIMM1705ZZ-01] ; Syngenta-SIMM-PhD Studentship Project[00000000] ; "Youth Innovation Promotion Association" from Chinese Academy of Sciences[2016258] ; "Young Elite Scientists Sponsorship" from China Association for Science and Technology[2016QNRC001] ; Shanghai "Pujiang Program"[16PJ1410600] ; SA-SIBS Scholarship Program[00000000]
WOS关键词	SARCOPHYTON-TROCHELIOPHORUM MARENZELLER ; SESQUITERPENOIDS ; SKELETON
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000431726900032
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279766]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Li, Xu-Wen; Guo, Yue-Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 3.Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, 5 Yu Shan Rd, Qingdao 266003, Peoples R China; 4.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England; 5.CNR, Natl Res Council, Inst Biomol Chem ICB, Via Campi Flegrei 34, I-80078 Naples, Italy; 6.Qingdao Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Ye, Fei,Li, Jing,Wu, Yu,et al. Sarinfacetamides A and B, Nitrogenous Diterpenoids with Tricyclo[6.3.1.0(1,5)]dodecane Scaffold from the South China Sea Soft Coral Sarcophyton infundibuliforme[J]. ORGANIC LETTERS,2018,20(9):2637-2640.
APA	Ye, Fei.,Li, Jing.,Wu, Yu.,Zhu, Zheng-Dan.,Mollo, Ernesto.,...&Guo, Yue-Wei.(2018).Sarinfacetamides A and B, Nitrogenous Diterpenoids with Tricyclo[6.3.1.0(1,5)]dodecane Scaffold from the South China Sea Soft Coral Sarcophyton infundibuliforme.ORGANIC LETTERS,20(9),2637-2640.
MLA	Ye, Fei,et al."Sarinfacetamides A and B, Nitrogenous Diterpenoids with Tricyclo[6.3.1.0(1,5)]dodecane Scaffold from the South China Sea Soft Coral Sarcophyton infundibuliforme".ORGANIC LETTERS 20.9(2018):2637-2640.