Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis

doi:10.1016/j.phytol.2018.03.012

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis
	Xiong, Juan 1; Wu, Xi-Ying 1; Wang, Pei-Pei3 ; Lau, Choiwan 4; Fan, Hui 2; Ma, Guang-Lei 1; Tang, Yu 1; Li, Jia3 ; Hu, Jin-Feng 1
刊名	PHYTOCHEMISTRY LETTERS
	2018-06
卷号	25 页码:17-21
关键词	Gmelina hainanensis Endangered plant Acylated iridoid glycosides PTP1B inhibition
ISSN号	1874-3900
DOI	10.1016/j.phytol.2018.03.012
文献子类	Article
英文摘要	Two new (1 and 2) and 10 known (3-12) acylated iridoid diglycosides were isolated from the twigs and leaves of the cultivated endangered ornamental plant Gmelina hainanensis. Based on spectroscopic data interpretation and chemical transformation, the new triacyl and the new diacyl iridoid diglycosides were established to be 6-O-alpha-L-(2 '',3 ''-di-O-acetyl-4 ''-O-cis-cinnamoyl)rhamnopyranosylcatalpol (1) and 6-O-alpha-L-(2 '',4 ''-di-O-trans-cinnamoyl) rhamnopyranosylcatalpol (2), respectively. All the isolates were evaluated for their inhibitory effects against the protein tyrosine phosphatase 1 B (PTP1B) enzyme.
资助项目	NSFC[81773599] ; NSFC[21772025] ; NSFC[21472021] ; NSFC[21402052] ; MOST[2018ZX09735008]
WOS关键词	GLYCOSIDES ; DITERPENOIDS ; ARBOREA ; GLUCOSIDES ; PATTERNS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000433356000004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279735]
专题	药理学第三研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心国家新药筛选中心
通讯作者	Lau, Choiwan; Hu, Jin-Feng
作者单位	1.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201203, Peoples R China; 2.East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Medica, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Fudan Univ, Instrumental Anal Ctr, Sch Pharm, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Xiong, Juan,Wu, Xi-Ying,Wang, Pei-Pei,et al. Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis[J]. PHYTOCHEMISTRY LETTERS,2018,25:17-21.
APA	Xiong, Juan.,Wu, Xi-Ying.,Wang, Pei-Pei.,Lau, Choiwan.,Fan, Hui.,...&Hu, Jin-Feng.(2018).Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis.PHYTOCHEMISTRY LETTERS,25,17-21.
MLA	Xiong, Juan,et al."Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis".PHYTOCHEMISTRY LETTERS 25(2018):17-21.