Ruthenium-Promoted C-H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids

doi:10.1021/acs.orglett.8b01837

	Ruthenium-Promoted C-H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids
	Wang, Xuan 1,2; Sun, Hui 2; Liu, Jiaxiang 2; Dai, Dongcheng 1; Zhang, Mingqiang 1; Zhou, Hu2 ; Zhong, Wenge 1; Lu, Xiaojie2
刊名	ORGANIC LETTERS
	2018-08-17
卷号	20 期号:16 页码:4764-4768
ISSN号	1523-7060
DOI	10.1021/acs.orglett.8b01837
文献子类	Article
英文摘要	The first example of DNA-compatible C-H activation reaction between DNA-conjugated acrylamides and aromatic acids has been developed. This new transformation enables aromatic acid, previously considered as monofunctional building block, to act like a bifunctional building block for the DNA encoded library synthesis. The general scope of aromatic acid was established for this new on-DNA C-H activation, which paved the way for its application in combinatorial library preparation.
资助项目	National "'1000 Talents"' Young Scientist Grant[00000000] ; Amgen[00000000]
WOS关键词	ENCODED CHEMICAL LIBRARY ; TECHNOLOGY ELT ; BOND ACTIVATION ; TRYPSIN-INHIBITORS ; POTENT CLASS ; DISCOVERY ; WATER ; FUNCTIONALIZATION ; ALKENYLATIONS ; OLEFINATION
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000442454900011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279615]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhong, Wenge; Lu, Xiaojie
作者单位	1.Amgen Biopharmaceut R&D Shanghai Co Ltd, Amgen Asia R&D Ctr, 4560 Jinke Rd,Bldg 2,13th Floor, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Xuan,Sun, Hui,Liu, Jiaxiang,et al. Ruthenium-Promoted C-H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids[J]. ORGANIC LETTERS,2018,20(16):4764-4768.
APA	Wang, Xuan.,Sun, Hui.,Liu, Jiaxiang.,Dai, Dongcheng.,Zhang, Mingqiang.,...&Lu, Xiaojie.(2018).Ruthenium-Promoted C-H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids.ORGANIC LETTERS,20(16),4764-4768.
MLA	Wang, Xuan,et al."Ruthenium-Promoted C-H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids".ORGANIC LETTERS 20.16(2018):4764-4768.