Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki

doi:10.1016/j.fitote.2018.08.001

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki
	Xue, Jing-Jing 2; Lei, Chun 2; Wang, Pei-Pei1 ; Kim, Kwang-Yong 3; Li, Jing-Ya1 ; Li, Jia1 ; Hou, Ai-Jun 2
刊名	FITOTERAPIA
	2018-10
卷号	130 页码:37-42
关键词	Moraceae Broussonetia kazinoki Flavans 1,3-Diphenylpropanes Protein tyrosine phosphatase 1B
ISSN号	0367-326X
DOI	10.1016/j.fitote.2018.08.001
文献子类	Article
英文摘要	Three new (1a/1b and 2b) and five known flavans (2a, 6a/6b, 7, and 8), one new flavan glycoside (3), and two new (4 and 5) and six known 1,3-diphenylpropanes (9-14) were isolated from the twigs of Broussonetia kazinoki. Compounds 1, 2, and 6 are scalemic mixtures, and were resolved by chiral HPLC to provide 1a/1b, 2a/2b, and 6a/6b. The structures of these compounds were elucidated by extensive spectroscopic methods, including NMR, MS, and ECD analyses. Compounds 1, 2, 5, 8, 9, 11, and 12 showed in vitro inhibition of protein tyros ine phosphatase 1B (PTP1B).
资助项目	National Natural Science Foundation of China[21372049] ; National Natural Science Foundation of China[81222045] ; Key National Scientific and Technological Program "Major New Drug Development" of China[2018ZX09735001-002-006]
WOS关键词	ISOPRENYLATED PHENOLIC-COMPOUNDS ; TYROSINE-PHOSPHATASE 1B ; PAPER MULBERRY ; CONSTITUENTS ; DERIVATIVES ; PROTEIN ; FLAVONOIDS ; SIEB
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000449129500006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279549]
专题	药理学第三研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心国家新药筛选中心
通讯作者	Hou, Ai-Jun
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 2.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China; 3.Han Dock Su Pyongyang Univ Light Ind, Inst Analyt Chem, Pyongyang 999093, North Korea
推荐引用方式 GB/T 7714	Xue, Jing-Jing,Lei, Chun,Wang, Pei-Pei,et al. Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki[J]. FITOTERAPIA,2018,130:37-42.
APA	Xue, Jing-Jing.,Lei, Chun.,Wang, Pei-Pei.,Kim, Kwang-Yong.,Li, Jing-Ya.,...&Hou, Ai-Jun.(2018).Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki.FITOTERAPIA,130,37-42.
MLA	Xue, Jing-Jing,et al."Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki".FITOTERAPIA 130(2018):37-42.