Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages

doi:10.1016/j.jep.2008.09.026

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	Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages
	Hu, Xu-Dong 2; Yang, Yang 2; Zhong, Xiang-Gen 3; Zhang, Xiang-Hua 1; Zhang, Yi-Nan 1; Zheng, Zong-Ping 1; Zhou, Yu3 ; Tang, Wei3 ; Yang, Yi-Fu 3; Hu, Li-Hong 1
刊名	JOURNAL OF ETHNOPHARMACOLOGY
	2008-12-08
卷号	120 期号:3 页码:447-451
关键词	Z23 Inducible nitric oxide synthase Cyclooxygenase2 Cytokine RAW264.7 macrophage
ISSN号	0378-8741
DOI	10.1016/j.jep.2008.09.026
文献子类	Article
英文摘要	Aim of the study: Fissistigma oldhamii (Hemsl.) Merr, a traditional Chinese herb medicine, is used for treating rheumatoid arthritis in China. In our previous study, an effective compound, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl) ethyl] propenamide (Z23), from this herb has showed potent immunosuppressive effects both in vitro and in vivo. However, its anti-inflammatory effect and mechanism is still need to explore. Materials and methods: We examined the in vitro effects of Z23 on the production of nitric oxide (NO), prostaglandin E2 (PGE2) and cytokines by lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Results: Z23 significantly decreased the production of PGE2, NO, tumour necrosis factor alpha (TNFalpha) and 116 production. Inducible nitric oxide synthase (iNOS) and cyclooxygenase2 (COX2) gene expression were also significantly reduced. Conclusions: These results demonstrated that Z23 exerted an anti-inflammatory effect through modulating the synthesis of several mediators and cytokines involved in the inflammatory process. This study provided evidence to understand the therapeutic effects of Fissistigma oldhamii (Hemsl.) Merr and indicated that Z23 has the potential for treatment of various inflammatory diseases where the overproduction of NO, PGE2 and inflammatory cytokines has been shown to play a role, e.g. rheumatoid arthritis. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
WOS关键词	NITRIC-OXIDE SYNTHASE ; ALVEOLAR MACROPHAGES ; IN-VITRO ; INHIBITION ; EXPRESSION ; BIOSYNTHESIS ; CYTOKINE ; MICE ; VIVO
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000261896500020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279410]
专题	上海中药现代化研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第一研究室
通讯作者	Hu, Li-Hong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Hu, Xu-Dong,Yang, Yang,Zhong, Xiang-Gen,et al. Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages[J]. JOURNAL OF ETHNOPHARMACOLOGY,2008,120(3):447-451.
APA	Hu, Xu-Dong.,Yang, Yang.,Zhong, Xiang-Gen.,Zhang, Xiang-Hua.,Zhang, Yi-Nan.,...&Zuo, Jian-Ping.(2008).Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages.JOURNAL OF ETHNOPHARMACOLOGY,120(3),447-451.
MLA	Hu, Xu-Dong,et al."Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages".JOURNAL OF ETHNOPHARMACOLOGY 120.3(2008):447-451.