Design and synthesis of biotin-tagged photoaffinity probes of jasmonates

doi:10.1016/j.bmc.2010.03.059

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	Design and synthesis of biotin-tagged photoaffinity probes of jasmonates
	Gu, Min2,3,4 ; Yan, Jianbin 1; Bai, Zhiyan 1; Chen, Yue-Ting4 ; Lu, Wei 2,3; Tang, Jie 2,3; Duan, Liusheng 1; Xie, Daoxin 1; Nan, Fa-Jun4
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2010-05-01
卷号	18 期号:9 页码:3012-3019
关键词	Jasmonate Coronatine Photoaffinity probes Synthesis
ISSN号	0968-0896
DOI	10.1016/j.bmc.2010.03.059
文献子类	Article
英文摘要	Jasmonates (JAs) are a class of oxylipin compounds that play diverse roles in plant defense and development. The F-box protein coronatine insensitive1 (COI1) plays a crucial role in the JA signaling pathway. To determine whether COI1 binds directly to jasmonates, three biotin-tagged photoaffinity probes for JAs, a jasmonic acid photoaffinity probe (PAJA), a JAIle photoaffinity probe (PAJAIle), and a coronatine photoaffinity probe (PACOR), were designed and synthesized based on analysis of JA structure-activity relationships and molecular modeling of the interaction between COI1 and JAs. Among them, PACOR exhibited the most significant biological activity in inhibiting root growth, promoting accumulation of JA-responsive proteins, and triggering COI1-JAZ1 interaction in Arabidopsis seedlings. PACOR is an effective tool for elucidating the interaction between COI1 and JA. (c) 2010 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[30630044] ; National Natural Science Foundation of China[30725049] ; National Natural Science Foundation of China[30800593] ; National Natural Science Foundation of China[90717103] ; National Natural Science Foundation of China[90813037]
WOS关键词	BOX PROTEIN TIR1 ; AUXIN RECEPTOR ; ARABIDOPSIS ; DEFENSE ; GROWTH ; GENE ; OCTADECANOIDS ; CORONATINE ; ACID ; BIOSYNTHESIS
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000277083400003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278904]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Xie, Daoxin
作者单位	1.Tsinghua Univ, Sch Life Sci, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China; 2.E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China; 3.E China Normal Univ, Inst Med Chem, Shanghai 200062, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening,State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Gu, Min,Yan, Jianbin,Bai, Zhiyan,et al. Design and synthesis of biotin-tagged photoaffinity probes of jasmonates[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(9):3012-3019.
APA	Gu, Min.,Yan, Jianbin.,Bai, Zhiyan.,Chen, Yue-Ting.,Lu, Wei.,...&Nan, Fa-Jun.(2010).Design and synthesis of biotin-tagged photoaffinity probes of jasmonates.BIOORGANIC & MEDICINAL CHEMISTRY,18(9),3012-3019.
MLA	Gu, Min,et al."Design and synthesis of biotin-tagged photoaffinity probes of jasmonates".BIOORGANIC & MEDICINAL CHEMISTRY 18.9(2010):3012-3019.