Phenolic components from Petasites tricholobus

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	Phenolic components from Petasites tricholobus
	Zhang Yong 2; Guo Fujiang 2; Zeng Peng 2; Jia Qi 2; Li Yiming 2; Zhu Weiliang3 ; Chen Kaixian4
刊名	China Journal of Chinese Materia Medica
	2012
卷号	37 期号:12 页码:1782-1787
关键词	Petasites tricholobus phenolic compound sulfonated benzyl glucoside composite
ISSN号	1001-5302
其他题名	毛裂蜂斗菜中酚类成分研究
文献子类	Article
英文摘要	Objective: To study the anti-inflammatory and antioxidant effects of Petasites tricholobus and its phenolic components.Method: Phenolic compounds were separated purified by column chromatographic methods such as macroporous resin D-101,silica gel,ODS,MCI GEL CHP 20P,Sephadex LH-20.Their structures were identified on the basis of physicochemical property and multiple spectral data.Result: Nineteen phenolic compounds were separated from 95% ethanol extracts from P.tricholobus Franch.and identified as sulfonated benzyl glucoside(1),3-(4beta-D-glucopyranosyloxy-3,5-dimethoxy)-phenyl-2E-propenol(2),dihydrosyringin(3),tangshenosides II(4),4-hydroxy-2,6-dimethoxyphenol-1-O-beta-D-glucopyranoside(5),4-hydroxymethyl-2,6-dimethoxyphenyl-1-O-beta-D-glucopyranoside(6),arbutin(7),rutin(8),kaempferol-3-O-alpha-L-rhamnopyranosyl-(16)-beta-D-glucopyranoside(9),quercetin-3-O-beta-D-glucopyranoside(10),kaempferol-3-O-beta-D-glucopyranoside(11),afzelin(12),petasiphenol(13),caffeic acid(14),chlorogenic acid(15),2-hydroxy-5-acetylbenzoic acid(16),p-hydroxy-benzoic acid(17),protocatechuic aldehyde(18),and p-hydroxy-phenylpropionic acid(19).Conclusion: Above result shows that phenolic compounds contained in P.tricholobus mainly include simple phenols,phenolic glycosides,coffee acid and flavonoid glycosides.Among them,compound 1 was separated from the composite family for the first time;compounds 2-7,9,11,12,16,19 were separated from the genus Petasites for the first time,and the others were separated from the plant for the first time.These compounds have been proved to have pharmacological effects such as anti-inflammation,antibiosis,antioxidantion.
资助项目	新药研究国家重点实验室开放课题[00000000] ; 上海市药剂学重点学科建设项目[00000000]
WOS研究方向	General & Internal Medicine (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4620707
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267821]
专题	天然药物化学研究室药物发现与设计中心
通讯作者	Zhu Weiliang
作者单位	1.Shanghai 201203, China. 2.Department of Phytochemistry,School of Pharmacy,Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; 3.State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.; 4.Department of Phytochemistry,School of Pharmacy,Shanghai University of Traditional Chinese Medicine;
推荐引用方式 GB/T 7714	Zhang Yong,Guo Fujiang,Zeng Peng,et al. Phenolic components from Petasites tricholobus[J]. China Journal of Chinese Materia Medica,2012,37(12):1782-1787.
APA	Zhang Yong.,Guo Fujiang.,Zeng Peng.,Jia Qi.,Li Yiming.,...&Chen Kaixian.(2012).Phenolic components from Petasites tricholobus.China Journal of Chinese Materia Medica,37(12),1782-1787.
MLA	Zhang Yong,et al."Phenolic components from Petasites tricholobus".China Journal of Chinese Materia Medica 37.12(2012):1782-1787.