ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN

doi:10.1111/j.1745-4514.2009.00318.x

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 新药研究国家重点实验室

	ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN
	Xin, Xuelei 1,2,3; Wang, Qi 4; Aisa, Haji Akber 2; Wang, Hanqing 1
刊名	JOURNAL OF FOOD BIOCHEMISTRY
	2010-08
卷号	34 期号:4 页码:811-824
ISSN号	0145-8884
DOI	10.1111/j.1745-4514.2009.00318.x
文献子类	Article
英文摘要	Nigella glandulifera Freyn, an annual plant species of the family Ranunculaceae, served as a traditional Uigur medicine and food. Many researchers have reported that Nigella sativa L., which is the same genus with it, has an antidiabetic effect, the seeds oil was an activity component used as a kind of function food. In the present study, the difference of oil extract between n-hexane and petroleum ether respectively from the seeds of Nigella glandulifera Freyn were analyzed by gas chromatography-mass spectrometry, all of them can inhibit protein tyrosine phosphatase 1B (PTP1B) with half maximal inhibitory concentration values of 33.15 +/- 0.77 and 18.50 +/- 0.52 mg/mL, respectively. They have different binding sites with PTP1B. Lastly, inhibited ability of PTP1B and that of TCPTP were compared; all of them have shown some selectivity.
资助项目	Foundation of the Chinese Academy of Sciences[KSCX2-YW-R-132] ; High technology and development program of Xinjiang Uigur Autonomous Region[200515123] ; Department of Science and Technology of Xinjiang Uigur Autonomous Region[200721110]
WOS关键词	SATIVA L. OIL ; FIXED OIL ; PTP1B ; RATS ; MICE
WOS研究方向	Biochemistry & Molecular Biology ; Food Science & Technology
语种	英语
出版者	WILEY
WOS记录号	WOS:000280643000008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278815]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Aisa, Haji Akber
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China; 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China; 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Xin, Xuelei,Wang, Qi,Aisa, Haji Akber,et al. ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN[J]. JOURNAL OF FOOD BIOCHEMISTRY,2010,34(4):811-824.
APA	Xin, Xuelei,Wang, Qi,Aisa, Haji Akber,&Wang, Hanqing.(2010).ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN.JOURNAL OF FOOD BIOCHEMISTRY,34(4),811-824.
MLA	Xin, Xuelei,et al."ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN".JOURNAL OF FOOD BIOCHEMISTRY 34.4(2010):811-824.